Circulating GLP-1 Levels in Patients with Pheochromocytoma/Paraganglioma

• Published in: International journal of endocrinology Vol. 2022; pp. 4203018 - 7
• Main Authors: Chen, Nan, Chen, Yan, Lai, Fenghua, Chen, Li, Zeng, Rui, Pei, Ling, Wu, Liting, Wang, Chenxue, Li, Yanbing, Xiao, Haipeng, Cao, Xiaopei
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 14.12.2022; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Body mass index; Care and treatment; Catecholamines; Correlation analysis; Creatinine; Dextrose; Diabetes; Endocrinology; Glucagon; Glucose; Health aspects; High density lipoprotein; Hormones; Hyperglycemia; Hypertension; Insulin resistance; Laboratories; Localization; Metabolic disorders; Metabolites; Neuroendocrine tumors; Plasma; Risk factors; Type 2 diabetes
• ISSN: 1687-8337; 1687-8345
• DOI: 10.1155/2022/4203018

The sympathoadrenal system has been shown to stimulate the secretory activity of enteroendocrine cells, although the response is transient. Our aim was to investigate the effects of long-term catecholamine excess on circulating glucagon-likepeptide-1 (GLP-1) levels in patients with pheochromocytoma/paraganglioma (PPGL). Thirty patients diagnosed with PPGL were analyzed. A significant negative association was observed between fasting plasma GLP-1 levels and elevated plasma-free metanephrine (r=−0.407,p=0.026). After adjustment for age, sex, body mass index (BMI), serum creatinine, and the presence of hyperglycemia, the negative association between plasma GLP-1 and metanephrine persisted by multiple linear regression analysis (β=−0.493,p=0.013). Positive correlations between fasting glucose and plasma metanephrine (r=0.380,p=0.038) and normetanephrine levels (r=0.450,p=0.013) were also found. Mean fasting levels of total GLP-1 increased significantly from 25.81 to 39.01 pmol/L (p=0.017) after PPGL resection. In conclusion, long-term overproduction of catecholamines appears to induce suppression of GLP-1 production compared to an acute response to a stress stimulus. Further studies are required to elucidate the mechanism of GLP-1 secretion with chronic exposure to catecholamine.