Overexpression of Hdac6 extends reproductive lifespan in mice

Dear Editor, Histone deacetylase 6 （Hdac6） was discovered as a deacetylase of e-tubulin and functions in cell migration, immunity and resistance to virus infection in vitro （Hubbert et al., 2002; Valenzuela-Fernandez et al., 2008）. Overexpression of Hdac6 enhances resistance to virus infection in em...

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Published inProtein & cell Vol. 8; no. 5; pp. 360 - 364
Main Authors Zhang, Xiaoxi, Yang, Jiao, Wang, Haiying, Guo, Renpeng, Yin, Yu, Zhang, Dongdong, Zhang, Qian, Wang, Hua, Zhou, Zhongcheng, Chen, Lingyi, Zhou, Jun, Liu, Lin
Format Journal Article
LanguageEnglish
Published Beijing Higher Education Press 01.05.2017
Springer Nature B.V
Oxford University Press
Subjects
Biochemistry
Biomedical and Life Sciences
Cell Biology
Developmental Biology
Human Genetics
Letter
Life Sciences
Protein Science
Stem Cells
Seminiferous Tubule
Relative Telomere Length
Embryonic Stem Cell
Telomere Length
H3K9me3 Level
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Summary:Dear Editor, Histone deacetylase 6 （Hdac6） was discovered as a deacetylase of e-tubulin and functions in cell migration, immunity and resistance to virus infection in vitro （Hubbert et al., 2002; Valenzuela-Fernandez et al., 2008）. Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem （ES） cells and in mice （Wang et al., 2015）. Hdac6 also can function to deacetyiate protein and is involved in protein ubiquitination and degradation （Seigneurin-Berny et al., 2001; Zhang et al., 2014）, and self- clearance of misfolded proteins, promoting autophagy and preventing neurodegeneration （Lee et al., 2010; Pandey et al., 2007）. HDAC6 also is implicated in DNA damage response and depletion or inhibition of HDAC6 induces DNA damage and apoptosis （Namdar et al., 2010; Zhang et al., 2014）, suggesting that HDAC6 could be important for DNA repair and integrity maintenance.
Bibliography:Dear Editor, Histone deacetylase 6 （Hdac6） was discovered as a deacetylase of e-tubulin and functions in cell migration, immunity and resistance to virus infection in vitro （Hubbert et al., 2002; Valenzuela-Fernandez et al., 2008）. Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem （ES） cells and in mice （Wang et al., 2015）. Hdac6 also can function to deacetyiate protein and is involved in protein ubiquitination and degradation （Seigneurin-Berny et al., 2001; Zhang et al., 2014）, and self- clearance of misfolded proteins, promoting autophagy and preventing neurodegeneration （Lee et al., 2010; Pandey et al., 2007）. HDAC6 also is implicated in DNA damage response and depletion or inhibition of HDAC6 induces DNA damage and apoptosis （Namdar et al., 2010; Zhang et al., 2014）, suggesting that HDAC6 could be important for DNA repair and integrity maintenance.
11-5886/Q
SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
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ISSN:1674-800X
1674-8018
1674-8018
DOI:10.1007/s13238-017-0375-9