Peripheral Blood S100B Levels in Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

• Published in: Journal of autism and developmental disorders Vol. 51; no. 8; pp. 2569 - 2577
• Main Authors: Zheng, Zhen, Zheng, Peng, Zou, Xiaobing
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2021; Springer; Springer Nature B.V
• Subjects: Analysis; Anatomy; Autism; Autism Spectrum Disorders; Behavioral Science and Psychology; Biological markers; Blood; Brain; Calcium; Calcium-binding protein; Central nervous system; Child and School Psychology; Chinese; Control Groups; Database Management Systems; Genetic aspects; Genetics; Individualized Instruction; Influence of Technology; Interpersonal Relationship; Mental Disorders; Meta Analysis; Metabolism; Nervous system; Neurological Impairments; Neurosciences; Original Paper; Pediatrics; Peripheral blood; Peripheral circulation; Pervasive Developmental Disorders; Psychology; Public Health; S100b protein; Sample Size; Schizophrenia; Statistical Analysis; Systematic review; China; S100B; Autism spectrum disorder; Blood; Meta-analysis
• ISSN: 0162-3257; 1573-3432; 1573-3432
• DOI: 10.1007/s10803-020-04710-1

The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD) = 0.97, 95% confidence interval (95% CI) = 0.41–1.53; p  < 0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD.