Bone marrow PMN-MDSCs and neutrophils are functionally similar in protection of multiple myeloma from chemotherapy

• Published in: Cancer letters Vol. 371; no. 1; pp. 117 - 124
• Main Authors: Ramachandran, Indu R, Condamine, Thomas, Lin, Cindy, Herlihy, Sarah E, Garfall, Alfred, Vogl, Dan T, Gabrilovich, Dmitry I, Nefedova, Yulia
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.02.2016; Elsevier Limited
• Subjects: Animals; Antibiotics; Antibiotics, Antineoplastic - pharmacology; Antigens; Antineoplastic Agents, Alkylating - pharmacology; Apoptosis - drug effects; Bone marrow; Cancer; Cell Line, Tumor; Cell Lineage; Chemoresistance; Chemotherapy; Coculture Techniques; Colleges & universities; Disease Models, Animal; Doxorubicin - pharmacology; Drug Resistance, Neoplasm; Experiments; Genotype & phenotype; Growth factors; Hematology, Oncology and Palliative Medicine; Humans; Immunotherapy; Melphalan - pharmacology; Mice, Inbred C57BL; Multiple myeloma; Multiple Myeloma - drug therapy; Multiple Myeloma - metabolism; Multiple Myeloma - pathology; Myeloid Cells - drug effects; Myeloid Cells - metabolism; Myeloid Cells - pathology; Myeloid-derived suppressor cells; Neutrophils; Neutrophils - drug effects; Neutrophils - metabolism; Neutrophils - pathology; Paracrine Communication; Phenotype; Time Factors; Tumor Cells, Cultured; Tumor Microenvironment; MDSC; MNC; Chemoresistance; BM; immature myeloid cells; macrophages; dendritic cells; PMN-MDSC; monocytic MDSC; plasmacytoid DC; IMC; MM; multiple myeloma; cDC; M-MDSC; Neutrophils; conventional DC; BMS; bone marrow stroma; TME; bone marrow; myeloid-derived suppressor cells; pDC; polymorphonuclear MDSC; mononuclear cell; MΦ; tumor microenvironment; DC; Myeloid-derived suppressor cells; Multiple myeloma
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2015.10.040

Highlights • Myeloid cells play a critical role in regulation of myeloma growth. • PMN-MDSCs and neutrophils equally protect myeloma cells from chemotherapy. • PMN-MDSCs and neutrophils mediate chemoprotective effect through soluble factors.