DECILORUBICIN, A NEW ANTHRACYCLINE ANTIBIOTIC

A new antitumor antibiotic, decilorubicin has been found in the culture broth of Streptomyces virginiae which was isolated from a soil sample collected at Nishi-Shinagawa, Tokyo. The antibiotic exhibits an antibacterial activity against gram-positive bacteria and a prolongation effect on experimenta...

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Published inJournal of antibiotics Vol. 36; no. 4; pp. 451 - 453
Main Authors ISHII, KIYOTO, KONDO, SHINICHI, NISHIMURA, YOSHIO, HAMADA, MASA, TAKEUCHI, TOMIO, UMEZAWA, HAMAO
Format Journal Article
LanguageEnglish
Published Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1983
Subjects
Animals
Anthracyclines
Antibiotics, Antineoplastic - isolation & purification
Antibiotics, Antineoplastic - pharmacology
Fermentation
Mice
Naphthacenes - isolation & purification
Naphthacenes - pharmacology
Streptomyces - metabolism
Streptomyces virginiae
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Summary:A new antitumor antibiotic, decilorubicin has been found in the culture broth of Streptomyces virginiae which was isolated from a soil sample collected at Nishi-Shinagawa, Tokyo. The antibiotic exhibits an antibacterial activity against gram-positive bacteria and a prolongation effect on experimental mouse leukemia L-1210. Decilorubicin consists of an anthracyclinone chromophore, rhodosamine and four other sugars.
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ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.36.451