Dissociable contributions of MRI volume reductions of superior temporal and fusiform gyri to symptoms and neuropsychology in schizophrenia

Abstract We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory...

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Published inSchizophrenia research Vol. 91; no. 1; pp. 103 - 106
Main Authors Nestor, Paul G, Onitsuka, Toshiaki, Gurrera, Ronald J, Niznikiewicz, Margaret, Frumin, Melissa, Shenton, Martha E, McCarley, Robert W
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 01.03.2007
Elsevier Science
Subjects
Adolescent
Adult
Adult and adolescent clinical studies
Affect
Biological and medical sciences
Chronic Disease
Cognition Disorders - diagnosis
Cognition Disorders - etiology
Face
Functional Laterality - physiology
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Memory Disorders - diagnosis
Memory Disorders - etiology
Middle Aged
MRI
Neuropsychological Tests
Neuropsychology
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - complications
Schizophrenia - physiopathology
Severity of Illness Index
Symptoms
Temporal Lobe - anatomy & histology
Temporal Lobe - physiopathology
Schizophrenia
Neuropsychology
MRI
Symptoms
Psychosis
Human
Symptomatology
Medical imagery
Nuclear magnetic resonance imaging
Neuropsychologia
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Summary:Abstract We sought to identify the functional correlates of reduced magnetic resonance imaging (MRI) volumes of the superior temporal gyrus (STG) and the fusiform gyrus (FG) in patients with chronic schizophrenia. MRI volumes, positive/negative symptoms, and neuropsychological tests of facial memory and executive functioning were examined within the same subjects. The results indicated two distinct, dissociable brain structure-function relationships: (1) reduced left STG volume-positive symptoms-executive deficits; (2) reduced left FG-negative symptoms-facial memory deficits. STG and FG volume reductions may each make distinct contributions to symptoms and cognitive deficits of schizophrenia.
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Corresponding author. Department of Psychology, University of Massachusetts-Boston, Boston, MA 02125-3393, United States. Tel.: +1 617 287 6387. paul.nestor@umb.edu (P.G. Nestor).
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2006.11.025