FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development

• Published in: Cancer letters Vol. 362; no. 1; pp. 70 - 82
• Main Authors: Jin, Yue, Shenoy, Anitha K, Doernberg, Samuel, Chen, Hao, Luo, Huacheng, Shen, Huangxuan, Lin, Tong, Tarrash, Miriam, Cai, Qingsong, Hu, Xin, Fiske, Ryan, Chen, Ting, Wu, Lizi, Mohammed, Kamal A, Rottiers, Veerle, Lee, Siu Sylvia, Lu, Jianrong
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 28.06.2015; Elsevier Limited
• Subjects: Animals; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Caenorhabditis elegans; Cancer; Cell adhesion & migration; Cell cycle; Cell growth; Disease Progression; E-cadherin; EMT; Epidermis; Epidermis - growth & development; Epidermis - metabolism; Epithelial-Mesenchymal Transition; F-box; F-Box Proteins - genetics; F-Box Proteins - metabolism; Female; Gene expression; Genotype & phenotype; Hematology, Oncology and Palliative Medicine; Humans; Male; MCF-7 Cells; Metastasis; Mice; Mice, Inbred C57BL; Morphogenesis; Physiology; Protein-Arginine N-Methyltransferases - genetics; Protein-Arginine N-Methyltransferases - metabolism; Proteins; Rodents; Scratch; Snai1; Snail Family Transcription Factors; Spermatogenesis; Transcription factors; Transcription Factors - metabolism; Ubiquitination; Epidermis; Scratch; Snai1; F-box; E-cadherin; EMT
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2015.03.037

Highlights • FBXO11 interacts with and degrades the EMT-driving Snail transcription factors. • FBXO11 inhibits EMT and tumor invasion and is a favorable prognostic factor. • FBXO11 deficient mice show increased Snail protein levels and epidermal hyperplasia. • Epistasis analysis in C. elegans validates the FBXO11-Snail regulatory axis.