Biologic predictors of serologic responses to HPV in oropharyngeal cancer: The HOTSPOT study

Highlights • Abs to the HPV16 proteome were measured in 116 cases of OPC and 81 controls. • Serum Abs to HPV16 early Ags were detected in 90.6% of HPVOPC cases and 7.4% of controls. • Seropositivity to E6 and E2 was associated with oral HPV 16 copy number.

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Bibliographic Details
Published inOral oncology Vol. 51; no. 8; pp. 751 - 758
Main Authors Anderson, Karen S, Gerber, Jennifer E, D’Souza, Gypsyamber, Pai, Sara I, Cheng, Julia N, Alam, Rizwan, Kesiraju, Sailaja, Chowell, Diego, Gross, Neil D, Haddad, Robert, Gillison, Maura L, Posner, Marshall
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.08.2015
Subjects
Adult
Antibodies
Antibodies, Viral - blood
Biomarker
Biomarkers, Tumor - blood
Case-Control Studies
Enzyme-Linked Immunosorbent Assay
Female
Hematology, Oncology and Palliative Medicine
HPV
Human papillomavirus 16 - immunology
Humans
Immunoglobulin G - blood
Male
Middle Aged
Oropharyngeal cancer
Oropharyngeal Neoplasms - virology
Otolaryngology
Papillomavirus Infections - virology
Real-Time Polymerase Chain Reaction
Risk Factors
Serology
Sexual Partners
Biomarker
In vitro transcription/translation
Serology
IVTT
HPV
Abs
Oropharyngeal cancer
enzyme-linked immunosorbent assay
HPVOPC
rapid antigenic protein in situ display
HPV-positive oropharyngeal cancer
antibodies
RAPID
ELISA
Antibodies
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Summary:Highlights • Abs to the HPV16 proteome were measured in 116 cases of OPC and 81 controls. • Serum Abs to HPV16 early Ags were detected in 90.6% of HPVOPC cases and 7.4% of controls. • Seropositivity to E6 and E2 was associated with oral HPV 16 copy number.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1368-8375
1879-0593
DOI:10.1016/j.oraloncology.2015.05.007