Risk factors for incident chronic insomnia: A general population prospective study

• Published in: Sleep medicine Vol. 13; no. 4; pp. 346 - 353
• Main Authors: Singareddy, Ravi, Vgontzas, Alexandros N, Fernandez-Mendoza, Julio, Liao, Duanping, Calhoun, Susan, Shaffer, Michele L, Bixler, Edward O
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2012
• Subjects: Adult; Aged; Alcohol Drinking - epidemiology; Chronic insomnia; Coffee; Depression; Depression - diagnosis; Depression - epidemiology; Depression - psychology; Ethnic groups; Female; Follow-Up Studies; General population; Historical account; Humans; Incidence; Male; Mental disorders; Mental health; Mental Health - statistics & numerical data; Middle Aged; MMPI; Morbidity; Mortality; Neurology; Obesity; Obesity - epidemiology; Pennsylvania - epidemiology; Personality; Physical health; Polysomnography; Predictive Value of Tests; Prospective Studies; Risk Factors; Sleep Initiation and Maintenance Disorders - diagnosis; Sleep Initiation and Maintenance Disorders - epidemiology; Sleep Initiation and Maintenance Disorders - psychology; Sleep Medicine; Smoking - epidemiology; Vulnerability; Young Adult; Pennsylvania; AHI; MANCOVA; Minnesota Multiphasic Personality Inventory; Chronic insomnia; PSG; body mass index; Physical health; Mental health; General population; Depression; apnea/hypopnea index; multivariate analysis of covariance; Incidence; MMPI-2; polysomnography; BMI
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2011.10.033

Abstract Objective The few population-based, prospective studies that have examined risk factors of incident insomnia were limited by small sample size, short follow-up, and lack of data on medical disorders or polysomnography. We prospectively examined the associations between demographics, behavioral factors, psychiatric and medical disorders, and polysomnography with incident chronic insomnia. Methods From a random, general population sample of 1741 individuals of the adult Penn State Sleep Cohort, 1395 were followed-up after 7.5 years. Only subjects without chronic insomnia at baseline ( n = 1246) were included in this study. Structured medical and psychiatric history, personality testing, and 8-h polysomnography were obtained at baseline. Structured sleep history was obtained at baseline and follow-up. Results Incidence of chronic insomnia was 9.3%, with a higher incidence in women (12.9%) than in men (6.2%). Younger age (20–35 years), non-white ethnicity, and obesity increased the risk of chronic insomnia. Poor sleep and mental health were stronger predictors of incident chronic insomnia compared to physical health. Higher scores in MMPI-2, indicating maladaptive personality traits, and excessive use of coffee at baseline predicted incident chronic insomnia. Polysomnographic variables, such as short sleep duration or sleep apnea, did not predict incident chronic insomnia. Conclusion Mental health, poor sleep, and obesity, but not sleep apnea, are significant risk factors for incident chronic insomnia. Focusing on these more vulnerable groups and addressing the modifiable risk factors may help reduce the incident of chronic insomnia, a common and chronic sleep disorder associated with significant medical and psychiatric morbidity and mortality.