Berberine in Sepsis: Effects, Mechanisms, and Therapeutic Strategies

• Published in: Journal of Immunology Research Vol. 2023; pp. 4452414 - 8
• Main Authors: Lv, Tingxia, Zhang, Chunpan, Hu, Lan, Wang, Chao, Li, Shirong, Wang, He, Qi, Wenjie
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 25.01.2023; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Animal models; Animals; Anti-inflammatory drugs; Bacteria; Berberine; Berberine - pharmacology; Berberine - therapeutic use; Biomarkers; Coronaviruses; COVID-19; Development and progression; Health aspects; Herbal medicine; Immune response; Immunology; Infection; Inflammation; Intensive care; Kidneys; Medicine, Chinese Traditional; Metabolism; Mortality; Permeability; Protein expression; Proteins; Review; Risk factors; Sepsis; Sepsis - drug therapy; Traditional Chinese medicine; Viral infections; China
• ISSN: 2314-8861; 2314-7156
• DOI: 10.1155/2023/4452414

Sepsis is defined as a dysregulated immune response to infection that leads to multiple organ dysfunction. To date, though a growing body of knowledge has gained insight into the clinical risk factors, pathobiology, treatment response, and recovery methods, sepsis remains a significant concern and clinical burden. Therefore, further study is urgently needed to alleviate the acute and chronic outcomes. Berberine (BBR), a traditional Chinese medicine with multiple actions and mechanisms, has been investigated in cellular and rodent animal models of sepsis mainly based on its anti-inflammatory effect. However, the practical application of BBR in sepsis is still lacking, and it is imperative to systematically summarize the study of BBR in sepsis. This review summarized its pharmacological activities and mechanisms in septic-related organ injuries and the potential BBR-based therapeutic strategies for sepsis, which will provide comprehensive references for scientific research and clinical application.