Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features

• Published in: Schizophrenia research Vol. 109; no. 1; pp. 94 - 97
• Main Authors: Bergen, Sarah E, Fanous, Ayman H, Walsh, Dermot, O'Neill, F. Anthony, Kendler, Kenneth S
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.04.2009; Elsevier
• Subjects: Adult and adolescent clinical studies; association; Biological and medical sciences; Delusions - genetics; Family; GABRB3; Gene Frequency; Genetic Markers - genetics; Genetic Predisposition to Disease - genetics; Genetic Variation; Genome-Wide Association Study; Genotype; Hallucinations - genetics; Humans; MAOB; Medical sciences; Membrane Transport Proteins - genetics; modifier; Monoamine Oxidase - genetics; PAH; Phenylalanine Hydroxylase - genetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Psychotic Disorders - diagnosis; Psychotic Disorders - genetics; Psychotic Disorders - psychology; Receptors, GABA - genetics; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - genetics; Serotonin Plasma Membrane Transport Proteins - genetics; SERT; SLC6A4; GABRB3; SERT; MAOB; PAH; modifier; association; schizophrenia; SLC6A4; Human; Schizophrenia; Genetic determinism; Psychosis; Genetics; Polymorphism
• ISSN: 0920-9964; 1573-2509
• DOI: 10.1016/j.schres.2009.02.009

Abstract We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor β-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F = 8.0, p = .031) and QPDTPHASE (chi-square = 12.54, p = .028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square = 15.51, p = .030), but not QTDT (chi-square = 2.07, p = .560).