Anti-anxiety effect of ovary lipid extracted from Skipjack Tuna (Katsuwonus pelamis) in rats

• Published in: Journal of Veterinary Medical Science Vol. 69; no. 6; pp. 633 - 636
• Main Authors: Ookawa, K.(Shizuoka-ken. Industrial Research Inst. (Japan)), Mochizuki, K, Shida, E, Suzuki, T, Ooba, T, Matumoto, T, Hokari, Y, Hashidume, M, Yokogoshi, H
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.06.2007; Japan Science and Technology Agency
• Subjects: Animals; Anti-Anxiety Agents - isolation & purification; Anti-Anxiety Agents - therapeutic use; anxiety; Anxiety - drug therapy; BEHAVIOUR; COMPORTAMIENTO; COMPORTEMENT; Diazepam - therapeutic use; elevated plus-maze test; Euthynnus pelamis; Female; Katsuwonus; KATSUWONUS PELAMIS; LIPIDE; LIPIDOS; LIPIDS; Lipids - therapeutic use; Marine; OVAIRE; OVARIES; OVARIOS; Ovary - chemistry; ovary lipid; Pelamis; RAT; RATA; RATS; Thunnus; Time Factors; Tuna
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.69.633

Using an elevated plus-maze test, we evaluated anxiety level in rats given ovary lipid extracted from Skipjack tuna (Katsuwonus pelamis; OLS). The percentage of open time was significantly higher in rats given OLS than in rats in the control group, but lower than in rats given diazepam (1.0 mg/kg body weight). Based on this fact and findings about other indicators, this study showed that OLS does not have as fast-acting and strong an anti-anxiety effect as diazepam but that continuous ingestion of OLS causes an anti-anxiety effect in animals.