Neuroinflammation in the normal aging hippocampus

• Published in: Neuroscience Vol. 309; pp. 84 - 99
• Main Authors: Barrientos, R.M, Kitt, M.M, Watkins, L.R, Maier, S.F
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 19.11.2015
• Subjects: Aging - drug effects; Aging - immunology; Aging - psychology; Animals; danger signals; Hippocampus - drug effects; Hippocampus - immunology; Humans; Memory - drug effects; Memory - physiology; memory impairments; Microglia - drug effects; Microglia - immunology; microglial priming; neuroendocrine dysregulation; Neuroimmunomodulation - drug effects; Neuroimmunomodulation - physiology; neuroinflammation; Neurology; normal aging; complement receptor 3; glucocorticoid receptor; glutamate transporter subtype 1; IL-1 receptor antagonist; POCD; JNK; CD11b; interleukin-6; tumor necrosis factor-alpha; mitogen-activated protein; TBI; brain-derived neurotrophic factor; 11β-HSD1; major histocompatibility complex II; GLT1; IL-1RA; traumatic brain injury; neuroendocrine dysregulation; IL-1β; IL-6; CORT; ROS; 11β-hydroxysteroid dehydrogenase type 1; memory impairments; lipopolysaccharide; MAP; ERK; long-term potentiation; Nucleotide-binding domain, Leucine-Rich Repeat, Pyrin domain containing protein 3; MHC II; LTP; LPS; neuroinflammation; reactive oxygen species; NLRP3; GC; c-jun N-terminal kinase; glucocorticoid; BDNF; CCI; post-operative cognitive decline; normal aging; GR; controlled cortical impact; ICM; interleukin-1 beta; TNF-α; microglial priming; corticosterone; extracellular signal-regulated protein kinase; intra cisterna magna; danger signals
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.03.007

Highlights • Following challenge, the normal aged neuroinflammatory response is potentiated. • Sensitized microglia appears to be the source of this amplified response. • Elevated glucocorticoids may play a role in sensitizing microglia. • Potentiated neuroinflammation in the hippocampus leads to memory impairments. • Anti-inflammatory (e.g., exercise) interventions are effective treatments.