The role of parkin in familial and sporadic Parkinson's disease

• Published in: Movement disorders Vol. 25; no. S1; pp. S32 - S39
• Main Authors: Dawson, Ted M., Dawson, Valina L.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 2010; Wiley
• Subjects: AIMP2; Animals; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; FBP-1; Humans; Medical sciences; mitochondria; Mitochondria - metabolism; Mutation - genetics; Neurology; Parkinson Disease - classification; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; PINK1; proteasome; ubiquitin; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitin; Multicatalytic endopeptidase complex; FBP-1; proteasome; Nervous system diseases; Sporadic; Enzyme; Parkinson disease; Cerebral disorder; Peptidases; AIMP2; Familial disease; Mitochondria; PINK1; Central nervous system disease; Hydrolases; Degenerative disease; Extrapyramidal syndrome; Parkin
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.22798

Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic role in both inherited and sporadic PD. Here, we review parkin biology and pathobiology and its role in the pathogenesis of PD. © 2010 Movement Disorder Society