Regional segmentation of ventricular models to achieve repolarization dispersion in cardiac electrophysiology modeling
SummaryThe electrocardiogram (ECG) is one of the most significant outputs of a computational model of cardiac electrophysiology because it relates the numerical results to clinical data and is a universal tool for diagnosing heart diseases. One key features of the ECG is the T‐wave, which is caused...
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Published in | International journal for numerical methods in biomedical engineering Vol. 31; no. 8; pp. np - n/a |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
01.08.2015
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | SummaryThe electrocardiogram (ECG) is one of the most significant outputs of a computational model of cardiac electrophysiology because it relates the numerical results to clinical data and is a universal tool for diagnosing heart diseases. One key features of the ECG is the T‐wave, which is caused by longitudinal and transmural heterogeneity of the action potential duration (APD). Thus, in order to model a correct wave of repolarization, different cell properties resulting in different APDs must be assigned across the ventricular wall and longitudinally from apex to base. To achieve this requirement, a regional parametrization of the heart is necessary. We propose a robust approach to obtain the transmural and longitudinal segmentation in a general heart geometry without relying on ad hoc procedures. Our approach is based on auxiliary harmonic lifting analyses, already used in the literature to generate myocardial fiber orientations. Specifically, the solution of a sequence of Laplace boundary value problems allows parametrically controlled segmentation of both heart ventricles. The flexibility and simplicity of the proposed method is demonstrated through several representative examples, varying the locations and extents of the epicardial, midwall, and endocardial layers. Effects of the control parameters on the T‐wave morphology are illustrated via computed ECGs. Copyright © 2015 John Wiley & Sons, Ltd.
A new approach is presented to obtain the transmural and longitudinal segmentation of the heart. The proposed approach is based on auxiliary harmonic lifting analyses (A), results in different layouts of the transmural and longitudinal layers (B), allows assignment of different cell properties to different heart regions producing physiological action potential duration gradients (C), and leads to a physiologically correct electrocardiogram T‐wave (D). This approach can be used to study heart diseases or drugs affecting the T‐wave morphology. |
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Bibliography: | ArticleID:CNM2718 istex:B98886436CE0F9335F725F61A445A1A36F26DE1B ark:/67375/WNG-7KKRLFC5-R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2040-7939 2040-7947 |
DOI: | 10.1002/cnm.2718 |