Replication of Feline Syncytial Virus in Feline T-Lymphoblastoid Cells and Induction of Apoptosis in the Cells

• Published in: MICROBIOLOGY and IMMUNOLOGY Vol. 41; no. 5; pp. 431 - 435
• Main Authors: Ikeda, Yasuhiro, Itagaki, Shin-lchi, Tsutsui, Shigeki, Inoshima, Yasuo, Fukasawa, Masashi, Tomonaga, Keizo, Tohya, Yukinobu, Maeda, Ken, Mochizuki, Masami, Miyazawa, Takayuki, Mikami, Takeshi
• Format: Journal Article
• Language: English
• Published: Tokyo Blackwell Publishing Ltd 01.01.1997; Center For Academic Publications Japan; Center for Academic Publications Japan
• Subjects: Animals; Antigens, Viral - analysis; Apoptosis; Biological and medical sciences; Cats; Cell Line; DNA Fragmentation; Feline syncytial virus; Fundamental and applied biological sciences. Psychology; Microbiology; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains; Spumavirus - immunology; Spumavirus - physiology; T-Lymphocytes - cytology; T-Lymphocytes - virology; Tumor Cells, Cultured; Virology; Virus Replication; Tropism; Retroviridae; Spumavirinae; Host virus relation; In vitro; Virus; Pathogenicity; Cell death; Infectivity; T-Lymphocyte; Feline syncytial virus; Cytopathology; Infected cell; Lymphoblastoid cell; Apoptosis
• ISSN: 0385-5600; 1348-0421
• DOI: 10.1111/j.1348-0421.1997.tb01875.x

Feline syncytial virus (FSV) was isolated from feline peripheral blood mononuclear cells of FSV-seropositive cats. When the susceptibility of feline T-lymphocytes to FSV was examined using three strains of FSV, FSV antigens were detected in the FSV-infected T-lymphoblastoid cells. Further, a diversity of biological properties, including replication kinetics and syncytia formation, was noted among the strains, and condensation of chromatin and the fragmentation of cellular DNA were observed in the infected cells. From these data, we conclude that FSV is lymphotropic and can induce apoptosis in the lymphocytes.