Multi‐channel wireless mapping of gastrointestinal serosal slow wave propagation

• Published in: Neurogastroenterology and motility Vol. 27; no. 4; pp. 580 - 585
• Main Authors: Paskaranandavadivel, N., Wang, R., Sathar, S., O'Grady, G., Cheng, L. K., Farajidavar, A.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.04.2015
• Subjects: Animals; dysrhythmia; Electrodes; Electrophysiological Phenomena; Female; gastric electrical activity; Gastrointestinal Motility - physiology; Stomach - physiology; Swine; Telemetry - methods; wireless signal acquisition; Wireless Technology; wireless signal acquisition; gastric electrical activity; dysrhythmia
• ISSN: 1350-1925; 1365-2982; 1365-2982
• DOI: 10.1111/nmo.12515

Background High‐resolution (HR) extracellular mapping allows accurate profiling of normal and dysrhythmic slow wave patterns. A current limitation is that cables traverse the abdominal wall or a natural orifice, risking discomfort, dislodgement or infection. Wireless approaches offer advantages, but a multi‐channel system is required, capable of recording slow waves and mapping propagation with high fidelity. Methods A novel multi‐channel (n = 7) wireless mapping system was developed and compared to a wired commercial system. Slow wave signals were recorded from the porcine gastric and intestinal serosa in vivo. Signals were simultaneously acquired using both systems, and were filtered and processed to map activation wavefronts. For validation, the frequency and amplitude of detected events were compared, together with the speed and direction of mapped wavefronts. Key Results The wireless device achieved comparable signal quality to the reference device, and slow wave frequencies were identical. Amplitudes of the acquired gastric and intestinal slow wave signals were consistent between the devices. During normal propagation, spatiotemporal mapping remained accurate in the wireless system, however, during ectopic dysrhythmic pacemaking, the lower sampling resolution of the wireless device led to reduced accuracy in spatiotemporal mapping. Conclusions & Inferences A novel multichannel wireless device is presented for mapping slow wave activity. The device achieved high quality signals, and has the potential to facilitate chronic monitoring studies and clinical translation of spatiotemporal mapping. The current implementation may be applied to detect normal patterns and dysrhythmia onset, but HR mapping with finely spaced arrays currently remains necessary to accurately define dysrhythmic patterns. Validation of gastrointestinal slow wave recordings from a novel multi‐channel wireless electrophysiological recording system via a commercial wired system. The development of a novel multi‐channel wireless system will allow for studies of slow wave recordings in a chronic state in normal and diseased subjects.