MMP-9联合NT-proBNP在非ST段抬高急性冠脉综合征危险分层的研究

目的探讨N末端脑钠肽（NT-proBNP）、基质金属蛋白酶-9（MMP-9）在非ST段抬高急性冠脉综合征（NSTEACS）危险分层、预后评估中的作用及相互关系。方法连续收入因胸闷、胸痛至我院心内科住院的NSTE-ACS患者共114例,按照GRACE评分分为高危、中危、低危组,另设正常对照组58例,酶联免疫吸附法测定MMP-9浓度,电化学发光法测定NT-proBNP浓度,Gensini积分表示冠脉病变程度,并对主要不良心脏事件（MACE）的发生情况进行随访6个月。结果 1MMP-9、lgNT-proBNP水平在各组间具有显著性差异（P〈0.05）;2ROC曲线分析显示lgNTproBNP水平可预...

Full description

Saved in:
Bibliographic Details
Published in西安交通大学学报（医学版） Vol. 37; no. 3; pp. 313 - 317
Main Author 张春艳 王聪霞 李永勤 韩振华 张岩 吴皓宇 权晓慧 马海霞
Format Journal Article
LanguageChinese
Published 西安交通大学第二附属医院心血管内科,陕西西安,710004%陕西省人民医院心血管内科,陕西西安,710068%西安市第一医院心血管内科,陕西西安,710002 2016
Subjects
N末端脑钠肽（NT-proBNP）
危险分层
基质金属蛋白酶-9（MMP-9）
非ST段抬高急性冠脉综合征（NSTE-ACS）
N末端脑钠肽(NT-proBNP)
N-terminal probrain natriuretic peptide
risk stratification
基质金属蛋白酶-9(MMP-9)
非ST段抬高急性冠脉综合征(NSTE-ACS)
matrix metalloproteinase-9
non-ST elevation acute coro-nary syndrome
危险分层
Online AccessGet full text

Cover

More Information
Summary:目的探讨N末端脑钠肽（NT-proBNP）、基质金属蛋白酶-9（MMP-9）在非ST段抬高急性冠脉综合征（NSTEACS）危险分层、预后评估中的作用及相互关系。方法连续收入因胸闷、胸痛至我院心内科住院的NSTE-ACS患者共114例,按照GRACE评分分为高危、中危、低危组,另设正常对照组58例,酶联免疫吸附法测定MMP-9浓度,电化学发光法测定NT-proBNP浓度,Gensini积分表示冠脉病变程度,并对主要不良心脏事件（MACE）的发生情况进行随访6个月。结果 1MMP-9、lgNT-proBNP水平在各组间具有显著性差异（P〈0.05）;2ROC曲线分析显示lgNTproBNP水平可预测NSTE-ACS随访期MACE,其曲线下面积为0.795,截断值2.069,相应NT-proBNP值为116.56ng/L;MMP-9水平可预测NSTE-ACS随访期MACE,其曲线下面积为0.696,截断值32.49ng/mL;2项指标均异常预测MACE的灵敏度为80.41%,特异度为82.19%,正确诊断指数为0.63。3Cox回归分析显示,MMP-9及NTproBNP均异常与随访期MACE发生率独立相关,OR值为3.751。结论 MMP-9与NT-proBNP可以作为NSTEACS危险分层的血清学指标,二者联合应用可显著提高MACE的风险预测水平。
Bibliography:matrix metalloproteinase-9; N-terminal probrain natriuretic peptide; non-ST elevation acute coro-nary syndrome; risk stratification
Objective To explore the role and relationship of N-terminal pro-brain natriuretic peptide （NT- proBNP） and matrix metalloproteinase-9 （MMP-9） in risk stratification and prognosis assessment of non-ST elevation acute coronary syndrome （NSTE-ACS）. Methods We recruited 114 patients with NSTE-ACS and classified them into three groups according to the GRACE risk stratification： high-risk, intermediate-risk and low- risk groups. Another 58 patients were recruited as controls. Arterial blood was collected before angiography for the measurement of serum NT-proBNP and MMP-9. Gensini score was used to evaluate the degree of coronary artery stenosis. All the patients were followed up for 6 months and MACE was observed and recorded. Results ~ The levels of lg NT-proBNP and MMP-9 significantly differed between the groups （P〈O. 05）. Q ROC curve analysis showed that lg NT-proBNP could predict M
ISSN:1671-8259
DOI:10.7652/jdyxb201603002