吉兰-巴雷综合征的100年

吉兰-巴雷综合征是主要累及周围神经的自身免疫性疾病。自1916年Guillain和Barré描述其核心临床特征后100年,随着对其临床表现多样性的认识,结合病理学、免疫学、电生理学和动物实验,其发病机制日趋明朗。本文从临床表现、病理生理学和发病机制、诊断标准、治疗与预后及吉兰-巴雷综合征与疫苗共5个方面按照年代顺序回顾吉兰-巴雷综合征100年的研究进展及其与临床实践发展之间的关系。...

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Bibliographic Details
Published in中国现代神经疾病杂志 Vol. 16; no. 9; pp. 548 - 559
Main Author 李海峰
Format Journal Article
LanguageChinese
Published 山东大学齐鲁医院神经内科,济南,250012 2016
Subjects
医学史
格林-巴利综合征
综述
格林-巴利综合征
综述
History of medicine
Review
医学史
Guillain-Barre syndrome
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Summary:吉兰-巴雷综合征是主要累及周围神经的自身免疫性疾病。自1916年Guillain和Barré描述其核心临床特征后100年,随着对其临床表现多样性的认识,结合病理学、免疫学、电生理学和动物实验,其发病机制日趋明朗。本文从临床表现、病理生理学和发病机制、诊断标准、治疗与预后及吉兰-巴雷综合征与疫苗共5个方面按照年代顺序回顾吉兰-巴雷综合征100年的研究进展及其与临床实践发展之间的关系。
Bibliography:Guillain-Barre syndrome; History of medicine; Review
LI Hai-feng （Department of Neurology, Qilu Hospital of Shandong University, Ji＇nan 250012, Shandong, China）
Guillain-Barre syndrome（GBS） is an autoimmune disease mainly involving the peripheral nervous system.Since the description of its core clinical features by Guillain and Barre 100 years ago,the understanding of pathogenesis of GBS was greatly improved with recognition of its clinical diversity,and studies on its pathology,immunology,electrophysiology and animal models.This paper reviews a 100-year history of research progress in its clinical manifestation,pathophysiology and pathogenesis,diagnostic criteria,treatment and outcomes,and the relationship with vaccination in chronological order,to give a comprehensive presentation on the relationship between research progress and the development of clinical practice in GBS.
12-1363/R
ISSN:1672-6731
DOI:10.3969/j.issn.1672-6731.2016.09.002