Circular RNAs: Biogenesis, Biological Functions, and Roles in Myocardial Infarction

Non-coding RNAs have been excavated as important cardiac function modulators and linked to heart diseases. Significant advances have been obtained in illuminating the effects of microRNAs and long non-coding RNAs. Nevertheless, the characteristics of circular RNAs are rarely mined. Circular RNAs (ci...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 24; no. 4; p. 4233
Main Authors Li, Jialei, Han, Yu, Wang, Shuang, Wu, Xiaolei, Cao, Jimin, Sun, Teng
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.02.2023
MDPI
Subjects
Binding sites
biogenesis
biological functions
Biomarkers
Biosynthesis
Cardiac function
circular RNAs
Coding
cyclization form
Heart
Heart attack
Heart attacks
Heart diseases
Humans
MicroRNA
MicroRNAs
miRNA
Myocardial Infarction
Non-coding RNA
Proteins
Review
RNA, Circular
RNA, Long Noncoding
Stem cells
Thrombosis
Transplantation
biogenesis
circular RNAs
cyclization form
myocardial infarction
biological functions
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Summary:Non-coding RNAs have been excavated as important cardiac function modulators and linked to heart diseases. Significant advances have been obtained in illuminating the effects of microRNAs and long non-coding RNAs. Nevertheless, the characteristics of circular RNAs are rarely mined. Circular RNAs (circRNAs) are widely believed to participate in cardiac pathologic processes, especially in myocardial infarction. In this review, we round up the biogenesis of circRNAs, briefly describe their biological functions, and summarize the latest literature on multifarious circRNAs related to new therapies and biomarkers for myocardial infarction.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24044233