Altered epigenetic regulation and increasing severity of bronchial hyperresponsiveness in atopic asthmatic children

[...]the net in vivo histone (de)acetylation activity (expressed as the ratio of HDAC/HAT activity) is skewed toward increased histone acetylation in allergic asthmatic subjects, with the intensity of increased cellular acetylation activity increasing with BHR severity.

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Bibliographic Details
Published inJournal of allergy and clinical immunology Vol. 124; no. 5; pp. 1116 - 1118
Main Authors Su, Ruey-Chyi, PhD, Becker, Allan B., MD, Kozyrskyj, Anita L., PhD, HayGlass, Kent T., PhD
Format Journal Article
LanguageEnglish
Published United States Mosby, Inc 01.11.2009
Elsevier Limited
Subjects
Acetylation
Allergy and Immunology
Asthma
Asthma - enzymology
Asthma - genetics
Asthma - immunology
Bronchial Hyperreactivity - enzymology
Bronchial Hyperreactivity - genetics
Bronchial Hyperreactivity - immunology
Case-Control Studies
Child
Chromatin
Chronic illnesses
Clinical outcomes
Cohort Studies
Epigenesis, Genetic
Epigenetics
Gene expression
Histone Acetyltransferases - immunology
Histone Acetyltransferases - metabolism
Histone Deacetylases - immunology
Histone Deacetylases - metabolism
Human subjects
Humans
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Summary:[...]the net in vivo histone (de)acetylation activity (expressed as the ratio of HDAC/HAT activity) is skewed toward increased histone acetylation in allergic asthmatic subjects, with the intensity of increased cellular acetylation activity increasing with BHR severity.
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ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2009.08.033