Genetic Basis of Pancreas Cancer Development and Progression: Insights from Whole-Exome and Whole-Genome Sequencing

Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor les...

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Bibliographic Details
Published inClinical cancer research Vol. 18; no. 16; pp. 4257 - 4265
Main Authors LACOBUZIO-DONAHUE, Christine A, VELCULESCU, Victor E, WOLFGANG, Christopher L, HRUBAN, Ralph H
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 15.08.2012
Subjects
Antineoplastic agents
Biological and medical sciences
Carcinoma, Pancreatic Ductal - genetics
Carcinoma, Pancreatic Ductal - pathology
Disease Progression
Family
Gastroenterology. Liver. Pancreas. Abdomen
Genome, Human
Germ-Line Mutation
Humans
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Neoplasm Invasiveness
Neoplasm Metastasis
Pancreatic Neoplasms - genetics
Pancreatic Neoplasms - pathology
Pharmacology. Drug treatments
Sequence Analysis, DNA
Tumors
Pancreas cancer
Tumor progression
Digestive diseases
Genetics
Malignant tumor
Genome
Carcinogenesis
Sequencing
Cancer
Pancreatic disease
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Summary:Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:1078-0432
1557-3265
DOI:10.1158/1078-0432.ccr-12-0315