Lung Adenocarcinoma with Chronic Lymphocytic Leukemia Mimicking Bone Metastasis

• Published in: Internal Medicine Vol. 62; no. 12; pp. 1801 - 1806
• Main Authors: Matsuoka, Takako, Miyazaki, Aoi, Kosai, Sachiyo, Nakamura, Kazuyoshi, Uramoto, Hideshi, Kobayashi, Hironori, Sakamoto, Osamu
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 15.06.2023; Japan Science and Technology Agency
• Subjects: Adenocarcinoma; Adenocarcinoma - diagnostic imaging; Adenocarcinoma - pathology; Adenocarcinoma of Lung - diagnostic imaging; Aged; Biopsy; bone lesion; Bone lesions; bone metastasis; Case Report; Chronic lymphocytic leukemia; Computed tomography; double malignancy; Humans; Internal medicine; Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging; lung adenocarcinoma; lung cancer; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - pathology; Lungs; Lymphatic leukemia; Male; Malignancy; Metastases; Positron emission tomography; Thorax; Tomography, X-Ray Computed; bone lesion; lung cancer; double malignancy; chronic lymphocytic leukemia; bone metastasis; lung adenocarcinoma
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.0112-22

A 77-year-old man was referred to our hospital for abnormal thoracic radiographs. Computed tomography (CT) revealed a 20-mm subpleural ground-glass opacity in the right S6 area. A CT-guided biopsy revealed lung adenocarcinoma. Fluorodeoxyglucose-positron emission tomography revealed multiple abnormal bone accumulations, and a subsequent biopsy of a left iliac bone lesion revealed chronic lymphocytic leukemia. A right lower lung lobectomy was performed for the lung adenocarcinoma (cT1bN0M0, stage IA2). An aggressive biopsy of the bone lesion confirmed a rare case of double primary malignancies, which determined the patient's treatment and outcomes.