Rafts defined: a report on the Keystone symposium on lipid rafts and cell function

The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23–28, 2006 in Steamboat Springs, CO) brought together biophysicists, biochemists, and cell biologists to discuss the structure and function of lipid rafts. What emerged from the meeting was a consensus definition of a membrane ra...

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Bibliographic Details
Published inJournal of lipid research Vol. 47; no. 7; pp. 1597 - 1598
Main Author Pike, Linda J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2006
American Society for Biochemistry and Molecular Biology
Elsevier
Subjects
cholesterol
membrane microdomains
Membrane Microdomains - chemistry
Membrane Microdomains - physiology
sphingolipids
sphingolipids
cholesterol
membrane microdomains
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Summary:The recent Keystone Symposium on Lipid Rafts and Cell Function (March 23–28, 2006 in Steamboat Springs, CO) brought together biophysicists, biochemists, and cell biologists to discuss the structure and function of lipid rafts. What emerged from the meeting was a consensus definition of a membrane raft: “Membrane rafts are small (10–200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.” This definition helps to clarify current thinking in a field that has been plagued by the heterogeneous and sometimes ephemeral nature of its subject.
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ISSN:0022-2275
1539-7262
DOI:10.1194/jlr.E600002-JLR200