The cofilin pathway in breast cancer invasion and metastasis

Recent evidence indicates that metastatic capacity is an inherent feature of breast tumours and not a rare, late acquired event. This has led to new models of metastasis. The interpretation of expression-profiling data in the context of these new models has identified the cofilin pathway as a major...

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Bibliographic Details
Published inNature reviews. Cancer Vol. 7; no. 6; pp. 429 - 440
Main Authors Condeelis, John, Wang, Weigang, Eddy, Robert
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.06.2007
Subjects
Actin Depolymerizing Factors - physiology
Animals
Breast cancer
Breast Neoplasms - pathology
Care and treatment
Cell Line, Tumor
Cells
Diagnosis
Drosophila melanogaster - embryology
Epidermal Growth Factor - metabolism
Female
Gene expression
Humans
Models, Biological
Models, Molecular
Morphogenesis
Motility
Neoplasm Invasiveness
Neoplasm Metastasis
Physiological aspects
Risk factors
Signal Transduction
United States
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Summary:Recent evidence indicates that metastatic capacity is an inherent feature of breast tumours and not a rare, late acquired event. This has led to new models of metastasis. The interpretation of expression-profiling data in the context of these new models has identified the cofilin pathway as a major determinant of metastasis. Recent studies indicate that the overall activity of the cofilin pathway, and not that of any single gene within the pathway, determines the invasive and metastatic phenotype of tumour cells. These results predict that inhibitors directed at the output of the cofilin pathway will have therapeutic benefit in combating metastasis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1474-175X
1474-1768
DOI:10.1038/nrc2148