The current research status of normal tension glaucoma

• Published in: Clinical interventions in aging Vol. 9; pp. 1563 - 1571
• Main Authors: Xue-Song Mi, Xuesong, Yuan, Ti-Fei, So, Kwok-Fai
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2014; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Aged; aging; Animals; Blood Pressure - physiology; degeneration; Disease; Disease Models, Animal; DNA Mutational Analysis; Drug therapy; Eye - blood supply; Family medical history; Female; Gene expression; Gene mutations; Genetic aspects; genetics; Glaucoma; Glaucoma, Open-Angle - diagnosis; Glaucoma, Open-Angle - genetics; Glaucoma, Open-Angle - physiopathology; Health aspects; Humans; Intraocular Pressure - physiology; Low Tension Glaucoma - diagnosis; Low Tension Glaucoma - genetics; Low Tension Glaucoma - physiopathology; Male; Mice, Transgenic; Mutation; Neurodegeneration; neuroprotection; neurovascular unit; normal tension glaucoma; Optic nerve; primary open-angle glaucoma; Prognosis; Retinal Vessels - physiopathology; Review; Risk Factors; Signal Transduction; Transgenic animals; treatment; China; Hong Kong; treatment; genetics; aging; primary open-angle glaucoma; neurovascular unit

Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlyin...