The current research status of normal tension glaucoma

• Published in: Clinical interventions in aging Vol. 9; pp. 1563 - 1571
• Main Authors: Xue-Song Mi, Xuesong, Yuan, Ti-Fei, So, Kwok-Fai
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2014; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Aged; aging; Animals; Blood Pressure - physiology; degeneration; Disease; Disease Models, Animal; DNA Mutational Analysis; Drug therapy; Eye - blood supply; Family medical history; Female; Gene expression; Gene mutations; Genetic aspects; genetics; Glaucoma; Glaucoma, Open-Angle - diagnosis; Glaucoma, Open-Angle - genetics; Glaucoma, Open-Angle - physiopathology; Health aspects; Humans; Intraocular Pressure - physiology; Low Tension Glaucoma - diagnosis; Low Tension Glaucoma - genetics; Low Tension Glaucoma - physiopathology; Male; Mice, Transgenic; Mutation; Neurodegeneration; neuroprotection; neurovascular unit; normal tension glaucoma; Optic nerve; primary open-angle glaucoma; Prognosis; Retinal Vessels - physiopathology; Review; Risk Factors; Signal Transduction; Transgenic animals; treatment; China; Hong Kong; treatment; genetics; aging; primary open-angle glaucoma; neurovascular unit
• ISSN: 1178-1998; 1176-9092; 1178-1998
• DOI: 10.2147/CIA.S67263

Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management.