The current research status of normal tension glaucoma
Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlyin...
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| Published in | Clinical interventions in aging Vol. 9; pp. 1563 - 1571 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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01.01.2014
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| Abstract | Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management. |
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| AbstractList | Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management. Keywords: aging, genetics, neurovascular unit, primary open-angle glaucoma, treatment Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management. Xue-Song Mi,1,2 Ti-Fei Yuan,3,4 Kwok-Fai So2,4,5 1Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic of China; 2Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China; 3School of Psychology, Nanjing Normal University, Nanjing, People's Republic of China; 4Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China; 5GHM Institute of CNS Regeneration, Jinan University, Guangzhou, People's Republic of China Abstract: Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management. Keywords: aging, genetics, neurovascular unit, primary open-angle glaucoma, treatment Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management.Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular pressure or other mitigating factors that can lead to optic neuropathy. The present review summarized the causes, genetics, and mechanisms underlying NTG in both animal models and human patients. We also proposed that the neurovascular unit is a therapeutic target for NTG management. |
| Audience | Academic |
| Author | Xue-Song Mi, Xuesong Yuan, Ti-Fei So, Kwok-Fai |
| AuthorAffiliation | 5 GHM Institute of CNS Regeneration, Jinan University, Guangzhou, People’s Republic of China 1 Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China 4 Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of China 2 Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People’s Republic of China 3 School of Psychology, Nanjing Normal University, Nanjing, People’s Republic of China |
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| Copyright | COPYRIGHT 2014 Dove Medical Press Limited 2014. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 Mi et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License 2014 |
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| Snippet | Normal tension glaucoma (NTG) is a progressive optic neuropathy that mimics primary open-angle glaucoma, but lacks the findings of elevated intraocular... Xue-Song Mi,1,2 Ti-Fei Yuan,3,4 Kwok-Fai So2,4,5 1Department of Ophthalmology, The First Affiliated Hospital of Jinan University, Guangzhou, People's Republic... |
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| SubjectTerms | Aged aging Animals Blood Pressure - physiology degeneration Disease Disease Models, Animal DNA Mutational Analysis Drug therapy Eye - blood supply Family medical history Female Gene expression Gene mutations Genetic aspects genetics Glaucoma Glaucoma, Open-Angle - diagnosis Glaucoma, Open-Angle - genetics Glaucoma, Open-Angle - physiopathology Health aspects Humans Intraocular Pressure - physiology Low Tension Glaucoma - diagnosis Low Tension Glaucoma - genetics Low Tension Glaucoma - physiopathology Male Mice, Transgenic Mutation Neurodegeneration neuroprotection neurovascular unit normal tension glaucoma Optic nerve primary open-angle glaucoma Prognosis Retinal Vessels - physiopathology Review Risk Factors Signal Transduction Transgenic animals treatment |
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| Title | The current research status of normal tension glaucoma |
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