Two Cases of Primary Biliary Cirrhosis Complicated by Acute Leukemia

• Published in: Internal Medicine Vol. 46; no. 9; pp. 561 - 563
• Main Authors: Saito, Hironobu, Monoe, Kyoko, Kanno, Yukiko, Takahashi, Atsushi, Rai, Tsuyoshi, Irisawa, Atsushi, Ohira, Hiromasa
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 01.01.2007
• Subjects: acute lymphoid leukemia; acute promyelocytic leukemia; Adult; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Blotting, Western; CREST Syndrome - complications; Dihydrolipoyllysine-Residue Acetyltransferase - metabolism; Fatal Outcome; Female; Humans; Leukemia, Promyelocytic, Acute - complications; Leukemia, Promyelocytic, Acute - drug therapy; Liver - pathology; Liver Cirrhosis, Biliary - complications; Liver Cirrhosis, Biliary - enzymology; Liver Cirrhosis, Biliary - pathology; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy; primary biliary cirrhosis
• ISSN: 0918-2918; 1349-7235; 1349-7235
• DOI: 10.2169/internalmedicine.46.6037

Case 1 was a 43-year-old woman, who was diagnosed as having PBC. After one month, she was hospitalized owing to sudden temporary unconsciousness. She was diagnosed as having acute lymphoid leukemia (ALL) by bone marrow examination. Chemotherapy was done, but she died after 6 months. Case 2 was a 54-year-old woman, who was diagnosed as having PBC with CREST syndrome. Seven years later, she was diagnosed as having acute promyelocytic leukemia (APL) by bone marrow examination. Chemotherapy was continued, and her symptoms are at present, stable. To date, there have been no reports of PBC complicated by acute leukemia.