Advances in regenerative therapy: A review of the literature and future directions

• Published in: Regenerative therapy Vol. 14; pp. 136 - 153
• Main Authors: Ntege, Edward H., Sunami, Hiroshi, Shimizu, Yusuke
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2020; Japanese Society for Regenerative Medicine; Elsevier
• Subjects: Adipose-derived stem cells; Ex vivo culture-expanded stem cells; Mesenchymal stem cells; Regenerative therapies; Review; Scaffold free-cellsheet technology; Scaffold-based cellsheet technology; Tissue derived stem cells; Tissue engineering; Tissue engineering; Tissue derived stem cells; Scaffold-based cellsheet technology; Adipose-derived stem cells; Ex vivo culture-expanded stem cells; Scaffold free-cellsheet technology; Regenerative therapies; Mesenchymal stem cells
• ISSN: 2352-3204; 2352-3204
• DOI: 10.1016/j.reth.2020.01.004

There is enormous global anticipation for stem cell-based therapies that are safe and effective. Numerous pre-clinical studies present encouraging results on the therapeutic potential of different cell types including tissue derived stem cells. Emerging evidences in different fields of research suggest several cell types are safe, whereas their therapeutic application and effectiveness remain challenged. Multiple factors that influence treatment outcomes are proposed including immunocompatibility and potency, owing to variations in tissue origin, ex-vivo methodologies for preparation and handling of the cells. This communication gives an overview of literature data on the different types of cells that are potentially promising for regenerative therapy. As a case in point, the recent trends in research and development of the mesenchymal stem cells (MSCs) for cell therapy are considered in detail. MSCs can be isolated from a variety of tissues and organs in the human body including bone marrow, adipose, synovium, and perinatal tissues. However, MSC products from the different tissue sources exhibit unique or varied levels of regenerative abilities. The review finally focuses on adipose tissue-derived MSCs (ASCs), with the unique properties such as easier accessibility and abundance, excellent proliferation and differentiation capacities, low immunogenicity, immunomodulatory and many other trophic properties. The suitability and application of the ASCs, and strategies to improve the innate regenerative capacities of stem cells in general are highlighted among others. •The current successes and challenges of cell-based therapies.•Basic strategies to enhance the innate potential in stem cells for therapy.•Experiences of applying ex vivo culture expanded stem cells in aesthetic surgery.