Metabolic Syndrome Increases Operative Mortality in Patients Undergoing Coronary Artery Bypass Grafting Surgery

• Published in: Journal of the American College of Cardiology Vol. 50; no. 9; pp. 843 - 851
• Main Authors: Echahidi, Najmeddine, MD, Pibarot, Philippe, DVM, PhD, FACC, FAHA, Després, Jean-Pierre, PhD, FAHA, Daigle, Jean-Marc, MSc, Mohty, Dania, MD, Voisine, Pierre, MD, Baillot, Richard, MD, Mathieu, Patrick, MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 28.08.2007; Elsevier Science; Elsevier Limited
• Subjects: Aged; Biological and medical sciences; Body mass index; Cardiology; Cardiology. Vascular system; Cardiovascular; Cholesterol; Comorbidity; Coronary Artery Bypass - mortality; Coronary Disease - epidemiology; Coronary Disease - surgery; Coronary heart disease; Coronary vessels; Diabetes Mellitus - epidemiology; Female; Heart; Heart attacks; Hospital Mortality; Humans; Internal Medicine; Male; Medical sciences; Metabolic diseases; Metabolic syndrome; Metabolic Syndrome - epidemiology; Middle Aged; Miscellaneous; Mortality; Multivariate Analysis; Other metabolic disorders; Prevalence; Retrospective Studies; Risk Factors; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the heart; Survival Analysis; Treatment Outcome; RR; CI; high-density lipoprotein; MS; myocardial infarction; relative risk; low-density lipoprotein; metabolic syndrome; HDL; LDL; confidence interval; CABG; MI; coronary artery bypass grafting; Endocrinopathy; Human; Prognosis; Mortality; Cardiovascular disease; Metabolic diseases; Patient; Increase; Coronary heart disease; Epidemiology; Phlebology; Treatment; Coronary artery bypass; X Syndrome; Graft; Circulatory system; Cardiology
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2007.04.075

Metabolic Syndrome Increases Operative Mortality in Patients Undergoing Coronary Artery Bypass Grafting Surgery Najmedine Echahidi, Philippe Pibarot, Jean-Pierre Després, Jean-Marc Daigle, Dania Mohty, Pierre Voisine, Richard Baillot, Patrick Mathieu We hypothesized that metabolic syndrome (MS) could increase operative mortality associated with coronary artery bypass grafting surgery (CABG). In a series of 5,304 patients undergoing isolated CABG, operative mortality was markedly increased among the 2,411 (46%) patients with MS defined according to the National Cholesterol Education Program—Adult Treatment Panel III guidelines. On multivariate analysis, MS was found to be a strong independent predictor of operative mortality irrespective of diabetes status. This is the first study to report that MS is a strong independent risk factor for operative mortality after CABG surgery.