Taste masking of ofloxacin and formation of interpenetrating polymer network beads for sustained release

• Published in: Journal of pharmaceutical analysis Vol. 7; no. 4; pp. 244 - 251
• Main Authors: Rajesh, A. Michael, Popat, Kiritkumar Mangaldas
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.08.2017; Xi'an Jiaotong University, Journal of Pharmaceutical Analysis; Academy of Scientific and Innovative Research, Central Salt and Marine Chemicals Research Institute, Council of Scientific & Industrial Research (CSIR), G.B. Marg, Bhavnagar 364002, India; Reverse Osmosis Membrane Division, Central Salt and Marine Chemicals Research Institute, Council of Scientific & Industrial Research (CSIR), G.B. Marg, Bhavnagar 364002, India; Xi'an Jiaotong University; Elsevier
• Subjects: Acids; Benzene; Biopolymers; Bitterness; Carboxymethylcellulose; Cellulose; Controlled release; Drug delivery; Drug delivery systems; exchange; Hydrocarbons; Hydrogels; in vivo & in vitro taste masking; Interpenetrating polymer network; Ion; Ion exchange resins; masking;Interpenetrating; Methacrylic acid; Methods; Molecular weight; network;Sustained; Nonsteroidal anti-inflammatory drugs; Ofloxacin; Original; pH effects; Pharmaceutical industry; polymer; Polymers; Potassium; release; Researchers; Resins; resins;Ofloxacin;in; Sodium; Studies; Sustained release; Taste; vitro; vivo; Xanthan gum; Mumbai India; India; Sustained release; Ion exchange resins; in vivo & in vitro taste masking; Ofloxacin; Interpenetrating polymer network
• ISSN: 2095-1779; 2214-0883
• DOI: 10.1016/j.jpha.2016.11.001

The objective of this study was to carry out taste masking of ofloxacin (Ofl) by ion exchange resins (IERs)followed by sustained release of Ofl by forming interpenetrating polymer network (IPN) beads. Drug-resin complexes (DRCs) with three different ratios of Ofl to IERs (1:1, 1:2, 1:4) were prepared by batch method and investigated for in vivo and in vitro taste masking. DRC of methacrylic acid-divinyl benzene (MD) resin and Ofl prepared at a ratio of 1:4 was used to form IPN beads. IPN beads of MD 1:4 were prepared by following the ionic cross-linking method using sodium carboxymethyl xanthan gum (SCMXG) and SCMXG-sodium carboxymethyl cellulose (SCMXG-SCMC). IPN beads were characterized with FT-IR and further studied on sustained release of Ofl at different pH. In vivo taste masking carried out by human volunteers showed that MD 1:4 significantly reduced the bitterness of Ofl.Characterization studies such as FT-IR, DSC, P-XRD and taste masking showed that complex formation took place between drug and resin. In vitro study at gastric pH showed complete release of drug from MD 1:4 within 30 min whereas IPN beads took 5 h at gastric pH and 10 h at salivary pH for the complete release of drug. As the crosslinking increased the release kinetics changed into non-Fickian diffusion to zero-order release mechanism. MD 1:4 showed better performance for the taste masking of Ofl and IPNs beads prepared from it were found useful for the sustained release of Ofl at both the pH, indicating a versatile drug delivery system.