PET imaging of amyloid deposition in patients with mild cognitive impairment

• Published in: Neurobiology of aging Vol. 29; no. 10; pp. 1456 - 1465
• Main Authors: Forsberg, Anton, Engler, Henry, Almkvist, Ove, Blomquist, Gunnar, Hagman, Göran, Wall, Anders, Ringheim, Anna, Långström, Bengt, Nordberg, Agneta
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2008
• Subjects: Aged; Aged, 80 and over; Aging - metabolism; Aging - pathology; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Amyloid; Amyloid beta-Peptides - metabolism; Benzothiazoles; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Cognition Disorders - diagnostic imaging; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Converters; CSF biomarkers; Disease Progression; FDG; Female; Fluorodeoxyglucose F18; Glucose - metabolism; Humans; Internal Medicine; Male; MEDICIN; MEDICINE; Middle Aged; Mild cognitive impairment; Neurology; Neuropsychological Tests; PET; PIB; Plaque, Amyloid - diagnostic imaging; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Positron-Emission Tomography; Predictive Value of Tests; Prognosis; Psychology; Psykologi; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Socialvetenskap; Mild cognitive impairment; Converters; PIB; FDG; Amyloid; CSF biomarkers; PET

It is of great clinical value to identify subjects at a high risk of developing AD. We previously found that the amyloid positron emission tomography (PET) tracer PIB showed a robust difference in retention in the brain between AD patients and healthy controls (HC). Twenty-one patients diagnosed wit...