PET imaging of amyloid deposition in patients with mild cognitive impairment

• Published in: Neurobiology of aging Vol. 29; no. 10; pp. 1456 - 1465
• Main Authors: Forsberg, Anton, Engler, Henry, Almkvist, Ove, Blomquist, Gunnar, Hagman, Göran, Wall, Anders, Ringheim, Anna, Långström, Bengt, Nordberg, Agneta
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2008
• Subjects: Aged; Aged, 80 and over; Aging - metabolism; Aging - pathology; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Amyloid; Amyloid beta-Peptides - metabolism; Benzothiazoles; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Cerebral Cortex - physiopathology; Cognition Disorders - diagnostic imaging; Cognition Disorders - pathology; Cognition Disorders - physiopathology; Converters; CSF biomarkers; Disease Progression; FDG; Female; Fluorodeoxyglucose F18; Glucose - metabolism; Humans; Internal Medicine; Male; MEDICIN; MEDICINE; Middle Aged; Mild cognitive impairment; Neurology; Neuropsychological Tests; PET; PIB; Plaque, Amyloid - diagnostic imaging; Plaque, Amyloid - metabolism; Plaque, Amyloid - pathology; Positron-Emission Tomography; Predictive Value of Tests; Prognosis; Psychology; Psykologi; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Socialvetenskap; Mild cognitive impairment; Converters; PIB; FDG; Amyloid; CSF biomarkers; PET
• ISSN: 0197-4580; 1558-1497; 1558-1497
• DOI: 10.1016/j.neurobiolaging.2007.03.029

It is of great clinical value to identify subjects at a high risk of developing AD. We previously found that the amyloid positron emission tomography (PET) tracer PIB showed a robust difference in retention in the brain between AD patients and healthy controls (HC). Twenty-one patients diagnosed with MCI (mean age 63.3 ± 7.8 (S.D.) years) underwent PET studies with 11C-PIB, and 18F-fluoro-deoxy-glucose (FDG) to measure cerebral glucose metabolism, as well as assessment of cognitive function and CSF sampling. Reference group data from 27 AD patients and 6 healthy controls, respectively, were used for comparison. The mean cortical PIB retention for the MCI patients was intermediate compared to HC and AD. Seven MCI patients that later at clinical follow-up converted to AD (8.1 ± 6.0 (S.D.) months) showed significant higher PIB retention compared to non-converting MCI patients and HC, respectively ( ps < 0.01). The PIB retention in MCI converters was comparable to AD patients ( p > 0.01). Correlations were observed in the MCI patients between PIB retention and CSF Aβ 1-42, total Tau and episodic memory, respectively.