双膦酸盐的今昔与思考

双膦酸盐（bisphosphonates,BPs）是近30年来研发的抗代谢性骨病的一类新药,能特异地与骨质中的羟磷灰石结合,抑制破骨细胞活性,从而抑制骨吸收。根据双膦酸盐类药物化学结构的变化,药物活性的改变,其抗骨吸收作用也不断增强,成为调节骨代谢、改善骨质疏松症状、降低骨折风险的一线抗骨质疏松药物。本文综述了双膦酸盐的发展史,第一代、第二代、第三代双膦酸盐的化学结构,第三代双膦酸盐抗骨吸收研究作用及临床实践中如何正确使用双膦酸盐,旨在为规范治疗骨质疏松提供科学的理论依据。...

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Bibliographic Details
Published in中国骨质疏松杂志 Vol. 23; no. 3; pp. 381 - 387
Main Author 张萌萌
Format Journal Article
LanguageChinese
Published 《中国骨质疏松杂志》社,北京,100102 2017
Subjects
双膦酸盐
唑来膦酸
应用前景
骨质疏松
骨质疏松
Osteoporosis
双膦酸盐
Prospects
应用前景
唑来膦酸
Zoledronate
Bisphosphonates
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Summary:双膦酸盐（bisphosphonates,BPs）是近30年来研发的抗代谢性骨病的一类新药,能特异地与骨质中的羟磷灰石结合,抑制破骨细胞活性,从而抑制骨吸收。根据双膦酸盐类药物化学结构的变化,药物活性的改变,其抗骨吸收作用也不断增强,成为调节骨代谢、改善骨质疏松症状、降低骨折风险的一线抗骨质疏松药物。本文综述了双膦酸盐的发展史,第一代、第二代、第三代双膦酸盐的化学结构,第三代双膦酸盐抗骨吸收研究作用及临床实践中如何正确使用双膦酸盐,旨在为规范治疗骨质疏松提供科学的理论依据。
Bibliography:ZHANG Mengmeng （ Chinese Journal of Osteoporosis, Beijing 100102, China）
Bisphosphonates（ bisphosphonates,BPs） was a newclass of anti-metabolic bone disease drugs developed in the past 30 years,which could specifically combine the hydroxyapatite in the bone,inhibit osteoclast activity,and inhibit bone resorption.According to the changes in the chemical structure of bisphosphonates,and the changes of drug activity,its anti-bone resorption effect was also increasing,it became the first-line anti-osteoporosis drugs with the regulation of bone metabolism, improve osteoporosis symptoms and reduce the risk of fracture activity.This paper reviewed the development of bisphosphonates,the chemical structures of the first,second,and third generation bisphosphonates,the role of the third-generation bisphosphonates in bone resorption,and the clinical application of bisphosphonates,which is intended to provide a scientific theoretical basis for the treatment of osteoporosis.
11-3701/R
Bisphosphonates; Osteoporosis; Zoledronat
ISSN:1006-7108
DOI:10.3969/j.issn.1006-7108.2017.03.021