Mechano-responses of quadriceps muscles evoked by transcranial magnetic stimulation

• Published in: Biomedizinische Technik
• Main Authors: Zakaria, Zafirah, Mazlan, Mazlina, Chung, Tze Yang, Selvanayagam, Victor S, Temesi, John, Magenthran, Vhinoth, Hamzaid, Nur Azah
• Format: Journal Article
• Language: English
• Published: Germany 25.09.2024
• Subjects: brain stimulation; rehabilitation; mechanomyography; knee extensors; human motor cortex
• ISSN: 0013-5585; 1862-278X
• DOI: 10.1515/bmt-2023-0501

Mechanomyography (MMG) may be used to quantify very small motor responses resulting from muscle activation, voluntary or involuntary. The purpose of this study was to investigate the MMG mean peak amplitude (MPA) and area under the curve (AUC) and the corresponding mechanical responses following delivery of transcranial magnetic stimulation (TMS) to the knee extensors. Fourteen adults (23 ± 1 years) received single TMS pulses at intensities from 30-80 % maximum stimulator output to elicit muscle responses in the relaxed knee extensors while seated. An accelerometer-based sensor was placed on the rectus femoris (RF) and vastus lateralis (VL) muscle bellies to measure the MMG signal. Pearson correlation revealed a positive linear relationship between MMG MPA and TMS intensity for RF (r=0.569; p<0.001) and VL (r=0.618; p<0.001). TMS intensity of ≥60 % maximum stimulator output produced significantly higher MPA than at 30 % TMS intensity and evoked measurable movement at the knee joint. MMG MPA was positively correlated to AUC (r=0.957 for RF and r=0.603 for VL; both p<0.001) and knee extension angle (r=0.596 for RF and r=0.675 for VL; both p<0.001). In conclusion, MMG captured knee extensor mechanical responses at all TMS intensities with the response increasing with increasing TMS intensity. These findings suggest that MMG can be an additional tool for assessing muscle activation.