血清Omentin-1水平与2型糖尿病并发骨质疏松症的相关性研究

目的探讨血清网膜素-1（Omentin-1）与2型糖尿病（T2DM）并发骨质疏松症的关系。方法选取30例T2DM伴骨质疏松患者（T2DM＋OP组）,30例T2DM不伴骨质疏松患者（T2DM组）,30例正常健康体检者（正常组）。酶联免疫吸附试验（ELISA）法测定血清Omentin-1、RANKL、OPG、OCN、TRAP-5b水平,并测定空腹血糖（FPG）、糖化血红蛋白（Hb A1c）、空腹胰岛素（FINS）等指标;BMD采用双能X线吸收骨密度仪扫描腰椎（L1-L4）检测。结果 1血清Omentin-1水平在T2DM＋OP组（31.90±2.95）μg/L、T2DM组（37.85±4.52）μ...

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Bibliographic Details
Published in中国骨质疏松杂志 Vol. 23; no. 2; pp. 141 - 144
Main Author 应大文 刘芳
Format Journal Article
LanguageChinese
Published 南华大学医学院,湖南衡阳,421000%岳阳市二人民医院,湖南岳阳,414000 2017
Subjects
2型糖尿病
网膜素-1
骨质疏松症
Osteoporosis
Omentin-1
骨质疏松症
Type 2 Diabetes Mellitus
网膜素-1
2型糖尿病
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Summary:目的探讨血清网膜素-1（Omentin-1）与2型糖尿病（T2DM）并发骨质疏松症的关系。方法选取30例T2DM伴骨质疏松患者（T2DM＋OP组）,30例T2DM不伴骨质疏松患者（T2DM组）,30例正常健康体检者（正常组）。酶联免疫吸附试验（ELISA）法测定血清Omentin-1、RANKL、OPG、OCN、TRAP-5b水平,并测定空腹血糖（FPG）、糖化血红蛋白（Hb A1c）、空腹胰岛素（FINS）等指标;BMD采用双能X线吸收骨密度仪扫描腰椎（L1-L4）检测。结果 1血清Omentin-1水平在T2DM＋OP组（31.90±2.95）μg/L、T2DM组（37.85±4.52）μg/L均明显低于正常人组（39.91±4.24）μg/L,T2DM＋OP组较T2DM组明显降低（P〈0.05）。2血清Omentin-1与OCN、OPG呈正相关（P〈0.01）,与FPG、Hb A1c、FINS、胰岛素抵抗指数（HOMA-IR）、RANKL及RANKL/OPG比值呈负相关（P〈0.01）。3Omentin-1是2型糖尿病骨质疏松的保护因素,而HOMA-IR及TRAP-5b为危险因素。结论血清网膜素-1在2型糖尿病并发骨质疏松的过程中逐渐降低,且伴有RANKL/OPG、TRAP-5b的增高。
Bibliography:Omentin-1;Type 2 Diabetes Mellitus;Osteoporosis
YING Dawen1 , LIU Fang2（1. Faculty of Medicine, South China University, Hengyang 42100, China; 2. Second Yueyang People＇ s Hospital, Yueyang 414000, China）
Objective To investigate the correlation between serum Omentin-1 and osteoporosis（OP） in patients with type 2diabetes（T2DM）.Methods 30 T2 DM patients with osteoporosis were enrolled as the T2 DM ＋ OP group,30 T2 DM patients without osteoporosis as the T2 DM group,and 30 healthy subjects were included in the control group.Enzyme-linked immuno sorbent assay（ELISA） was used to determine the levels of serum Omentin-1,osteocalcin（OCN）,RANKL,OPG and tartrate resistant acid phosphatase-5b（TRAP-5b）.The serum levels of FBG,HbAlC,and FINS were also measured.Bone mineral density（BMD） was measured using dual energy X-ray absorptiometry（DXA） at the lumber spine（L1-L4）.Results ①The serum Omentin-1 levels in T2 DM with OP group[（31.90 ±2.95） μg/L]and T2 DM group[（37.85 ±4.52） μg/L]were significantly lower than that in the con
ISSN:1006-7108
DOI:10.3969/j.issn.1006-7108.2017.02.001