Acute interstitial nephritis induced by Solanum nigrum

• Published in: Kidney research and clinical practice Vol. 35; no. 4; pp. 252 - 254
• Main Authors: Oh, Sung Sik, Choi, Myung Woo, Lee, Jong Hwa, Yang, Hyun Ju, Choi, Yeong Jin, Lee, Kwang Young, Sun, In O., MD
• Format: Journal Article
• Language: English
• Published: Korea (South) Elsevier B.V 01.12.2016; Elsevier; The Korean Society of Nephrology; 대한신장학회
• Subjects: Acute interstitial nephritis; Case Report; Corticosteroid; Nephrology; Solanum; 내과학; corticosteroid; Solanum; acute interstitial nephritis; Corticosteroid; Acute interstitial nephritis
• ISSN: 2211-9132; 2211-9140
• DOI: 10.1016/j.krcp.2016.05.003

Abstract Acute interstitial nephritis (AIN) is an important cause of reversible acute kidney injury and is pathologically characterized by inflammatory infiltrate in the renal interstitium. Solanum nigrum ( S. nigrum ) is a medicinal plant member of the Solanaceae family. While S. nigrum has been traditionally used to treat various ailments such as pain, inflammation, and fever, it has also been reported to have a toxic effect, resulting in anticholinergic symptoms. However, there have been no reports of AIN caused by S. nigrum . Here, we report the first case of biopsy-confirmed AIN following ingestion of S. nigrum . The patient was successfully treated using corticosteroid therapy.