Inflammatory Hepatocellular Adenoma with Elevated Serum Protein Induced by Vitamin K Absence/Antagonist-II in Adult Males

Two men (24 and 34 years of age) with a single hypervascular liver tumor were admitted to our hospital. The tumors were diagnosed as hepatocellular adenoma (HCA) by an ultrasound-guided biopsy and classified as inflammatory type by immunohistochemical staining. Considering the risk of malignant tran...

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Published inInternal Medicine Vol. 58; no. 12; pp. 1739 - 1746
Main Authors Koya, Yudai, Suzuki, Tomohiro, Tai, Mayumi, Ichii, Osamu, Matsuhashi, Nobuo, Ejiri, Yutaka, Miyazawa, Masatsugu, Shibata, Michihiko, Harada, Masaru, Kumabe, Tsutomu, Nakashima, Osamu
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 15.06.2019
Japan Science and Technology Agency
Subjects
Adenoma
beta-catenin activation
Biopsy
Case Report
Diagnosis
Inflammation
inflammatory hepatocellular adenoma
Internal medicine
Males
malignant transformation
Phylloquinone
protein induced by vitamin K absence/antagonist-II
Serum levels
Tumors
Ultrasound
Vitamin K
beta-catenin activation
inflammatory hepatocellular adenoma
malignant transformation
protein induced by vitamin K absence/antagonist-II
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Abstract Two men (24 and 34 years of age) with a single hypervascular liver tumor were admitted to our hospital. The tumors were diagnosed as hepatocellular adenoma (HCA) by an ultrasound-guided biopsy and classified as inflammatory type by immunohistochemical staining. Considering the risk of malignant transformation, they underwent surgical resection. Although the serum levels of protein induced by vitamin K absence/antagonist-II (PIVKA-II) were slightly elevated, they normalized after the resection. The diagnosis of HCA including malignant transformation is often difficult by image findings alone. Careful immunohistochemical examinations are very useful for the diagnosis and classification of subgroups, including malignant transformation. In addition, we proved that HCA without malignant transformation expresses PIVKA-II.
AbstractList Two men (24 and 34 years of age) with a single hypervascular liver tumor were admitted to our hospital. The tumors were diagnosed as hepatocellular adenoma (HCA) by an ultrasound-guided biopsy and classified as inflammatory type by immunohistochemical staining. Considering the risk of malignant transformation, they underwent surgical resection. Although the serum levels of protein induced by vitamin K absence/antagonist-II (PIVKA-II) were slightly elevated, they normalized after the resection. The diagnosis of HCA including malignant transformation is often difficult by image findings alone. Careful immunohistochemical examinations are very useful for the diagnosis and classification of subgroups, including malignant transformation. In addition, we proved that HCA without malignant transformation expresses PIVKA-II.
Author Tai, Mayumi
Nakashima, Osamu
Shibata, Michihiko
Kumabe, Tsutomu
Harada, Masaru
Ichii, Osamu
Matsuhashi, Nobuo
Miyazawa, Masatsugu
Koya, Yudai
Ejiri, Yutaka
Suzuki, Tomohiro
Author_xml – sequence: 1
  fullname: Koya, Yudai
  organization: The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan
– sequence: 2
  fullname: Suzuki, Tomohiro
  organization: Department of Gastroenterology, Fukushima Rosai Hospital, Japan
– sequence: 3
  fullname: Tai, Mayumi
  organization: Department of Gastroenterology, Fukushima Rosai Hospital, Japan
– sequence: 4
  fullname: Ichii, Osamu
  organization: Department of Gastroenterology, Fukushima Rosai Hospital, Japan
– sequence: 5
  fullname: Matsuhashi, Nobuo
  organization: Department of Gastroenterology, Fukushima Rosai Hospital, Japan
– sequence: 6
  fullname: Ejiri, Yutaka
  organization: Department of Gastroenterology, Fukushima Rosai Hospital, Japan
– sequence: 7
  fullname: Miyazawa, Masatsugu
  organization: Department of Surgery, Fukushima Rosai Hospital, Japan
– sequence: 8
  fullname: Shibata, Michihiko
  organization: The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan
– sequence: 9
  fullname: Harada, Masaru
  organization: The Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan
– sequence: 10
  fullname: Kumabe, Tsutomu
  organization: Kumabe Clinic, Japan
– sequence: 11
  fullname: Nakashima, Osamu
  organization: Department of Clinical Laboratory Medicine, Kurume University Hospital, Japan
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Issue 12
Keywords beta-catenin activation
inflammatory hepatocellular adenoma
malignant transformation
protein induced by vitamin K absence/antagonist-II
Language English
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Correspondence to Dr.　Yudai Koya, 58yudaikoya@gmail.com
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SubjectTerms Adenoma
beta-catenin activation
Biopsy
Case Report
Diagnosis
Inflammation
inflammatory hepatocellular adenoma
Internal medicine
Males
malignant transformation
Phylloquinone
protein induced by vitamin K absence/antagonist-II
Serum levels
Tumors
Ultrasound
Vitamin K
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Title Inflammatory Hepatocellular Adenoma with Elevated Serum Protein Induced by Vitamin K Absence/Antagonist-II in Adult Males
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