Inflammatory Hepatocellular Adenoma with Elevated Serum Protein Induced by Vitamin K Absence/Antagonist-II in Adult Males
Two men (24 and 34 years of age) with a single hypervascular liver tumor were admitted to our hospital. The tumors were diagnosed as hepatocellular adenoma (HCA) by an ultrasound-guided biopsy and classified as inflammatory type by immunohistochemical staining. Considering the risk of malignant tran...
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Published in | Internal Medicine Vol. 58; no. 12; pp. 1739 - 1746 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Japan
The Japanese Society of Internal Medicine
15.06.2019
Japan Science and Technology Agency |
Subjects | |
Online Access | Get full text |
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Summary: | Two men (24 and 34 years of age) with a single hypervascular liver tumor were admitted to our hospital. The tumors were diagnosed as hepatocellular adenoma (HCA) by an ultrasound-guided biopsy and classified as inflammatory type by immunohistochemical staining. Considering the risk of malignant transformation, they underwent surgical resection. Although the serum levels of protein induced by vitamin K absence/antagonist-II (PIVKA-II) were slightly elevated, they normalized after the resection. The diagnosis of HCA including malignant transformation is often difficult by image findings alone. Careful immunohistochemical examinations are very useful for the diagnosis and classification of subgroups, including malignant transformation. In addition, we proved that HCA without malignant transformation expresses PIVKA-II. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correspondence to Dr. Yudai Koya, 58yudaikoya@gmail.com |
ISSN: | 0918-2918 1349-7235 |
DOI: | 10.2169/internalmedicine.1958-18 |