COMPARISON OF DISAPPEARANCE FROM BLOOD AND LYMPHATIC DELIVERY OF HUMAN FIBROBLAST INTERFERON IN RAT BY DIFFERENT ADMINISTRATION ROUTES

• Published in: Journal of Pharmacobio-Dynamics Vol. 8; no. 3; pp. 206 - 210
• Main Authors: YOSHIKAWA, HIROSHI, SATOH, YU-ICHIRO, NARUSE, NORIO, TAKADA, KANJI, MURANISHI, SHOZO
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01.01.1985; Pharmaceutical Society of Japan
• Subjects: Animals; Biological and medical sciences; Half-Life; Humans; Immunomodulators; Injections, Intramuscular; Injections, Intraperitoneal; Injections, Intravenous; Injections, Subcutaneous; Interferon Type I - administration & dosage; Interferon Type I - metabolism; Lymph - metabolism; macromolecule; Male; Medical sciences; Micelles; Pharmacology. Drug treatments; Rats; Time Factors; Vertebrata; Mammalia; Metabolism; Route of administration; Rodentia; Beta interferon
• ISSN: 0386-846X; 1881-1353
• DOI: 10.1248/bpb1978.8.206

Disappearance from the blood and lymphatic delivery of human fibroblast interferon (HuIFN-β) in rats by the various administration routes were studied. Intravenous injection showed a rapid disappearance of HuIFN-β from the blood circulation, however, the clearance rate was greatly decreased after 2 h and the half-lives were 15 min and 2.0 h. Intramuscular, subcutaneous and intraperitoneal injections maintained readily detectable levels in the blood for 12 h, and the half-lives were 2.3, 1.7 and 1.2 h, respectively. Lipid-surfactant mixed micelles greatly promoted the absorption of HuIFN-β from the large intestine with extremely high selective lymphatic delivery, whereas intravenous and intramuscular injections showed no selective transfer into the lymphatics.