Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin

• Published in: Journal of Oleo Science Vol. 62; no. 3; pp. 181 - 186
• Main Authors: Maoka, Takashi, Yasui, Hiroyuki, Ohmori, Aya, Tokuda, Harukuni, Suzuki, Nobutaka, Osawa, Ayako, Shindo, Kazutoshi, Ishibashi, Takashi
• Format: Journal Article
• Language: English; Japanese
• Published: Japan Japan Oil Chemists' Society 01.03.2013; Japan Science and Technology Agency
• Subjects: 9,10-Dimethyl-1,2-benzanthracene - antagonists & inhibitors; adonirubin; adonixanthin; Animals; anti-carcinogenic activity; anti-oxidative activity; anti-tumor-promoting activity; Anticarcinogenic Agents - chemistry; Anticarcinogenic Agents - metabolism; Anticarcinogenic Agents - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Antioxidants - chemistry; Antioxidants - metabolism; Antioxidants - pharmacology; Canthaxanthin - analogs & derivatives; Canthaxanthin - biosynthesis; Canthaxanthin - chemistry; Canthaxanthin - pharmacology; Carotenoids - biosynthesis; Carotenoids - chemistry; Carotenoids - pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Lipid Peroxidation - drug effects; Mice; Mice, Inbred ICR; Molecular Structure; Paracoccus - chemistry; Paracoccus - metabolism; Singlet Oxygen - chemistry; Skin Neoplasms - chemically induced; Skin Neoplasms - drug therapy; Structure-Activity Relationship; Tetradecanoylphorbol Acetate - antagonists & inhibitors; Viral Matrix Proteins - antagonists & inhibitors
• ISSN: 1345-8957; 1347-3352
• DOI: 10.5650/jos.62.181

Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin, which are biosynthetic intermediates from β-carotene to astaxanthin, were investigated. Both adonirubin and adonixanthin showed almost the same activities for inhibition of lipid peroxidation and quenching of singlet oxygen as those of astaxanthin. Furthermore, adonirubin and adonixanthin exhibited an inhibitory effect on Epstein-Barr virus early antigen activation in Raji cells and carcinogensis of mouse skin tumors initiated by 7,12-dimethylbenz[a]anthracene and promoted by 12-O-tetradecanoylphorbol-13-acetate.