Formal Comment on "Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques" by Bochart et al. (2021)

[...]of these resistance patterns, the World Health Organization recently highlighted the need for new antimicrobials to treat fluoroquinolone-resistant Campylobacter and Shigella [6]. If AMR bacteria become more common in NHPs, potential spillover events may occur to humans leading to both serious...

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Bibliographic Details
Published inPLoS pathogens Vol. 18; no. 9; p. e1010831
Main Authors Bohm, Rudolf P, Breed, Matthew W, Cohen, Joyce K, Haertel, Andrew J, Halliday, Lisa C, Kramer, Joshua A, Lieberman, Mia T, Rice, Kelly A, Roberts, Jeffery A, Russell-Logrigue, Kasi E, Salyards, Gregory W, Scorpio, Diana G, Weese, J Scott
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.09.2022
Public Library of Science (PLoS)
Subjects
Animals
Anti-infective agents
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Biology and Life Sciences
Campylobacter
Combined Modality Therapy
Complications and side effects
Dosage and administration
Drug resistance
Drug resistance in microorganisms
Drug therapy
Formal Comment
Gastrointestinal diseases
Health care
Inflammation
Macaca mulatta
Medicine and Health Sciences
Mitigation
Pandemics
Pathogens
Public health
Reproducibility
Risk factors
Shigella
Simian Acquired Immunodeficiency Syndrome
Simian Immunodeficiency Virus
Staphylococcus infections
United States
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Summary:[...]of these resistance patterns, the World Health Organization recently highlighted the need for new antimicrobials to treat fluoroquinolone-resistant Campylobacter and Shigella [6]. If AMR bacteria become more common in NHPs, potential spillover events may occur to humans leading to both serious public health consequences and erosion of public trust in our research endeavors. The authors did not monitor any bacterial resistance patterns before or after the treatment or report antimicrobial susceptibility of common bacteria identified within the colony. [...]if this approach is used, it must be reported in the literature in the methods section of papers to promote research reproducibility.
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The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1010831