Epigenetic silencing of a multifunctional plant stress regulator
The central regulator of the ethylene (ET) signaling pathway, which controls a plethora of developmental programs and responses to environmental cues in plants, is ETHYLENE-INSENSITIVE2 (EIN2). Here we identify a chromatin-dependent regulatory mechanism at requiring two genes: ETHYLENE-INSENSITIVE6...
Saved in:
Published in | eLife Vol. 8 |
---|---|
Main Authors | , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
eLife Sciences Publications Ltd
16.08.2019
eLife Sciences Publications, Ltd |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The central regulator of the ethylene (ET) signaling pathway, which controls a plethora of developmental programs and responses to environmental cues in plants, is ETHYLENE-INSENSITIVE2 (EIN2). Here we identify a chromatin-dependent regulatory mechanism at
requiring two genes: ETHYLENE-INSENSITIVE6 (EIN6), which is a H3K27me3 demethylase also known as
(
), and EIN6 ENHANCER (EEN), the
homolog of the yeast INO80 chromatin remodeling complex subunit
(
). Strikingly, EIN6 (REF6) and the INO80 complex redundantly control the level and the localization of the repressive histone modification H3K27me3 and the histone variant H2A.Z at the 5' untranslated region (5'UTR) intron of
. Concomitant loss of EIN6 (REF6) and the INO80 complex shifts the chromatin landscape at
to a repressive state causing a dramatic reduction of
expression. These results uncover a unique type of chromatin regulation which safeguards the expression of an essential multifunctional plant stress regulator. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 USDOE Office of Science (SC) National Institutes of Health (NIH) FG02-04ER15517 Technology Commercialization, Drexel University, Philadelphia, United States. Department of Plant & Microbial Biology, Program in Genetics, North Carolina State University, Raleigh, United States. Department of Genetics, University of Georgia, Athens, United States. Bayer Crop Science, Chesterfield, United States. Illumina, San Diego, United States. Department of Animal, Plant and Soil Sciences, AgriBio Building, School of Life Sciences, La Trobe University, Melbourne, Australia. NAVICAN, San Diego, United States. Australian Research Council Research Hub for Medicinal Agriculture, AgriBio Building, School of Life Sciences, La Trobe University, Melbourne, Australia. |
ISSN: | 2050-084X 2050-084X |
DOI: | 10.7554/elife.47835 |