Formulation and in vitro Evaluation of Ketoprofen in Palm Oil Esters Nanoemulsion for Topical Delivery

• Published in: Journal of Oleo Science Vol. 59; no. 4; pp. 223 - 228
• Main Authors: Sakeena, M.H.F., F.A., Muthanna, Z.A., Ghassan, M.M., Kanakal, S.M., Elrashid, A.S., Munavvar, M.N., Azmin
• Format: Journal Article
• Language: English
• Published: Japan Japan Oil Chemists' Society 2010; Japan Science and Technology Agency
• Subjects: Administration, Topical; Cell Membrane Permeability; Chemistry, Pharmaceutical; Drug Delivery Systems; Emulsions; Esters; ketoprofen; Ketoprofen - administration & dosage; Ketoprofen - pharmacokinetics; Membranes, Artificial; Methylcellulose; Nanoparticles; Palm Oil; palm oil esters; Particle Size; Plant Oils; topical delivery; Water
• ISSN: 1345-8957; 1347-3352
• DOI: 10.5650/jos.59.223

The aim of the present study is to formulate and investigate the potential of nanoemulsion formulation for topical delivery of ketoprofen. In this study, Palm Oil Esters (POEs) a newly introduced oil by Universiti Putra Malaysia researchers was chosen for the oil phase of the nanoemulsion, because the oil was reported to be a good vehicle for pharmaceutical use. Oil-in-water nanoemulsion was prepared by spontaneous emulsification method. The droplets size was studied by laser scattering spectroscopy (Nanophox) and Transmission Electron Microscopy (TEM). Franz diffusion cells were used, to determine the drug release and drug transferred through methyl acetate cellulose membrane (artificial membrane). The results of droplets size analysis shows the droplets are in the range of nanoemulsion which is below than 500 nm. The in vitro release profile shows a sufficient percentage of drugs released through the methyl acetate cellulose membrane. This initial study showed that the nanoemulsion formulated using POEs has great potential for topical delivery of ketoprofen.