ISOLATION ON TREHALAMINE, THE AGLYCON OF TREHAZOLIN, FROM MICROBIAL BROTHS AND CHARACTERIZATION OF TREHAZOLIN RELATED COMPOUNDS

• Published in: Journal of antibiotics Vol. 46; no. 7; pp. 1116 - 1125
• Main Authors: ANDO, OSAMU, NAKAJIMA, MUTSUO, HAMANO, KIYOSHI, ITOI, KAZUKO, TAKAHASHI, SHUJI, TAKAMATSU, YASUYUKI, SATO, AKIRA, ENOKITA, RYUZO, OKAZAKI, TAKAO, HARUYAMA, HIDEYUKI, KINOSHITA, TAKESHI
• Format: Journal Article
• Language: English
• Published: Tokyo JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 1993; Japan Antibiotics Research Association
• Subjects: Actinobacteria - classification; Actinobacteria - metabolism; Animals; Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Applied microbiology; Biological and medical sciences; Bombyx; Chemotherapic agents; Disaccharides - metabolism; Fundamental and applied biological sciences. Psychology; Glycoside Hydrolases - antagonists & inhibitors; Hydrolysis; Microbiology; Micromonospora - classification; Micromonospora - metabolism; Molecular Structure; Nuts; Oxazoles - chemistry; Oxazoles - isolation & purification; Oxazoles - pharmacology; Rats; β-D-Glucosidase; Molecular structure; Enzyme; Micromonosporaceae; Micromonospora; Aglycone; Amycolatopsis; Enzyme inhibitor; Pseudonocardiaceae; Actinomycetales; Sucrose α-D-glucohydrolase; Microbial origin; Bacteria; Isolation; Actinomycetes; Physicochemical properties

Trehalamine, (3aR, 4R, 5S, 6S, 6aS)-2-amino-4-(hydroxymethyl)-3a, 5, 6, 6a-tetrahydro-4H-cyclopent[d]oxazole-4, 5, 6-triol (1) and D-glucose were obtained by acid hydrolysis of trehazolin (3), a trehalase inhibitor produced by actinomycetes. More vigorous hydrolytic treatment of trehazolin afforded...