Treatment of Class IV Lupus Nephritis with Mycophenolate Mofetil Monotherapy

Lupus nephritis (LN) occurs in up to 60% of systemic lupus erythematosus patients. Combination therapy involving a corticosteroid and cyclophosphamide or mycophenolate mofetil (MMF) has been a standard therapy for LN. However, clinicians generally prefer to minimize steroid use in LN treatment. We h...

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Published inInternal Medicine Vol. 57; no. 14; pp. 2067 - 2070
Main Authors Nawata, Takashi, Kubo, Makoto, Fujii, Shohei, Shiragami, Kosaku, Ikegami, Tadayoshi, Kobayashi, Shigeki, Hisano, Satoshi, Yano, Masafumi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 15.07.2018
Japan Science and Technology Agency
Subjects
Case Report
Congestive heart failure
Corticosteroids
Cyclophosphamide
Health risk assessment
Internal medicine
Lupus
Lupus nephritis
monotherapy
Mycophenolate mofetil
Mycophenolic acid
Nephritis
steroid-free
Steroids
Systemic lupus erythematosus
lupus nephritis
mycophenolate mofetil
steroid-free
monotherapy
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Summary:Lupus nephritis (LN) occurs in up to 60% of systemic lupus erythematosus patients. Combination therapy involving a corticosteroid and cyclophosphamide or mycophenolate mofetil (MMF) has been a standard therapy for LN. However, clinicians generally prefer to minimize steroid use in LN treatment. We herein report the case of a Japanese man with LN whose severe chronic heart failure prevented us from using steroid therapy. Instead, his LN was successfully treated with MMF monotherapy. Based on our experience with this case, we suggest that MMF monotherapy may represent a feasible LN treatment option in patients who cannot tolerate steroid therapy.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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Correspondence to Dr.　Makoto Kubo, mkubo@yamaguchi-u.ac.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.0304-17