Esophageal Carcinosarcoma that Was Diagnosed as a Granulocyte-colony Stimulating Factor and Interleukin-6-producing Tumor with a Tumor Fever

A 51-year-old man visited our hospital with a main complaint of precordial pain, difficulty swallowing, and pyrexia. The patient was diagnosed with esophageal carcinosarcoma, based on the characteristic morphology noted on upper gastrointestinal endoscopy and histology tests, and he underwent surgic...

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Published inInternal Medicine Vol. 57; no. 19; pp. 2819 - 2825
Main Authors Shioga, Taro, Matsushima, Shozo, Yamada, Eiji, Uchiyama, Takashi, Noto, Haruka, Suzuki, Daisuke, Nonaka, Takashi, Miyazawa, Shiro, Komatsu, Tatsuji, Yamamoto, Yuji, Sekido, Hitoshi, Niino, Hitoshi
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.10.2018
Japan Science and Technology Agency
Subjects
Carcinosarcoma - diagnosis
Carcinosarcoma - metabolism
Case Report
Colonies
Colony-stimulating factor
Cytokines
Deglutition Disorders - etiology
Endoscopy
Endoscopy, Digestive System
esophageal carcinosarcoma
Esophageal Neoplasms - diagnosis
Esophageal Neoplasms - metabolism
Esophagus
Fever
Fever - etiology
Granulocyte colony-stimulating factor
Granulocyte Colony-Stimulating Factor - metabolism
Granulocytes
Histology
Humans
Immunohistochemistry
Interleukin 6
Interleukin-6 - metabolism
Internal medicine
Leukocytes (granulocytic)
Male
Middle Aged
Pain
Swallowing
tumor fever
esophageal carcinosarcoma
granulocyte-colony stimulating factor
tumor fever
interleukin-6
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Summary:A 51-year-old man visited our hospital with a main complaint of precordial pain, difficulty swallowing, and pyrexia. The patient was diagnosed with esophageal carcinosarcoma, based on the characteristic morphology noted on upper gastrointestinal endoscopy and histology tests, and he underwent surgical treatment. His preoperative blood granulocyte-colony stimulating factor (G-CSF) and interleukin-6 (IL-6) levels were high, and the surgical specimens were positive in both immunohistochemical tests; therefore, he was diagnosed with a G-CSF- and IL-6-producing tumor. When pyrexia is seen as a paraneoplastic symptom, it is important to consider and investigate the possibility of a cytokine-producing tumor.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
Correspondence to Dr.　Shozo Matsushima, matsushima-shozo@yokohamamc.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.0677-17