Migratory Aortitis Associated with Granulocyte-colony-stimulating Factor

• Published in: Internal Medicine Vol. 59; no. 12; pp. 1559 - 1563
• Main Authors: Shirai, Tsuyoshi, Komatsu, Hiroka, Sato, Hiroko, Fujii, Hiroshi, Ishii, Tomonori, Harigae, Hideo
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 15.06.2020; Japan Science and Technology Agency
• Subjects: Aorta; Aortic arch; aortitis; Case Report; Case reports; chemotherapy; Colonies; Colony-stimulating factor; Granulocyte colony-stimulating factor; Granulocytes; Immunosuppression; Internal medicine; Leukocytes (granulocytic); migratory aortitis; Pancreatic cancer; Aortitis; Chemotherapy; Granulocyte-colony-stimulating factor; Migratory aortitis
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.4331-19

We herein report a case of migratory aortitis after the administration of granulocyte-colony-stimulating factor (G-CSF) to a 65-year-old woman with a history of pancreatic cancer. She was being administered pegfilgrastim and developed aortitis around the aortic arch. Although it resolved within two weeks, she again developed aortitis around the descending aorta, presenting as migratory aortitis, after pegfilgrastim was resumed. We further experienced three additional cases of G-CSF-induced aortitis that also showed spontaneous resolution, suggesting no or short-term use of immunosuppression. Aortitis due to G-CSF can present as migratory aortitis, since aortitis can quickly resolve and inflammation can recur at a different location.