Effect of vitamin C supplementation on lipid profile, serum uric acid, and ascorbic acid in children on hemodialysis

• Published in: Saudi journal of kidney diseases and transplantation Vol. 27; no. 6; pp. 1148 - 1154
• Main Authors: al-Mashad, Ghadah Muhammad, al-Sayyid, Hanan M. A., Nusayr, Nahlat A.
• Format: Journal Article
• Language: English
• Published: Riyadh, Saudi Arabia Saudi Center for Organ Transplantation 01.11.2016; Wolters Kluwer India Pvt. Ltd; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Analysis; Ascorbic Acid; Care and treatment; Child; Cholesterol; Disease; Health aspects; Hemodialysis; Hemodialysis patients; Humans; Hypertension; Kidney Failure, Chronic; Laboratories; Lipid Metabolism; Lipids; Lipoproteins test; Mortality; Oxidative stress; Plasma; Prospective Studies; Renal Dialysis; Studies; Uric Acid; Vitamin C; الأطفال; الليبيدات; المكملات الغذائية; حمض اليوريك; غسيل الكلى; فيتامين سي; Saudi Arabia
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.194602

Children with end-stage renal disease (ESRD) suffer from dyslipidemia and hyper- uricemia that might play a causal role in the progression of cardiovascular disease (CVD). The aim of the study is to assess the effects of Vitamin C supplementation on uric acid, ascorbic acid, and serum lipid levels among children on hemodialysis (HD). This prospective study was conducted in the pediatric nephrology unit at Menoufia University Hospital. The study included a total of 60 children with ESRD on maintenance HD therapy. They were divided into two groups: Group I (supplemented group, n = 30) received intravenous Vitamin C supplementation and Group II (control, n = 30) received placebo (intravenous saline) for three months. The results are shown as a mean ± standard deviation. Statistical evaluation was performed by SPSS software (version 11.5) using paired t-test. After supplementation with Vitamin C, the serum Vitamin C and high-density lipoprotein levels increased significantly with a significant reduction in the levels of serum uric acid, cholesterol, low-density lipoproteins, and triglyceride at the end of the study period. No significant changes were observed in the control group. Vitamin C can serve as a useful urate lowering medicine in HD patients to avoid complications of hyperuricemia. Furthermore, it had favorable effects on the lipid profile. This improvement can be considered as a preventive strategy in the progression of CVD in HD patients. Vitamin C supplementation improves ascorbic acid deficiency in these patien